The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.
The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.
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DOI：
10.1002/jor.23662
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Ward SR
中科院分区：
文献类型：
--
作者：
Gibbons MC;Singh A;Engler AJ;Ward SR
肩袖 (RC) 肌肉在因 RC 肌腱撕裂而导致机械卸载后会经历一些有害的变化。在这篇综述中，我们强调了整个肌肉、肌纤维和肌肉驻留细胞水平的机械改变的病理原因和后果，因为它们与 RC 疾病进展相关。简而言之，与 RC 撕裂相关的机械负荷改变会导致整个肌肉和肌纤维水平的结构、结构和成分变化。在细胞水平上，这些变化相当于机械生物学信号的直接破坏，而细胞和细胞外环境（也称为干细胞“生态位”）的机械调节生物物理和生化变化加剧了机械生物学信号的直接破坏。总之，这些数据对临床前模型和临床实践都具有重要意义。在临床前模型中，重要的是使用临床相关的损伤模式来概括人类中发现的萎缩性和退行性肌肉损失。在临床上，了解肌肉的力学和基础生物学将影响手术决策和康复方案，因为可能对萎缩肌肉有益的干预措施将对退化肌肉产生不利影响，反之亦然。
Rotator cuff (RC) muscles undergo several detrimental changes following mechanical unloading resulting from RC tendon tear. In this review, we highlight the pathological causes and consequences of mechanical alterations at the whole muscle, muscle fiber, and muscle resident cell level as they relate to RC disease progression. In brief, the altered mechanical loads associated with RC tear lead to architectural, structural, and compositional changes at the whole-muscle and muscle fiber level. At the cellular level, these changes equate to direct disruption of mechanobiological signaling, which is exacerbated by mechanically-regulated biophysical and biochemical changes to the cellular and extra-cellular environment (also known as the stem cell ‘niche’). Together, these data have important implications for both pre-clinical models and clinical practice. In pre-clinical models, it is important to recapitulate both the atrophic and degenerative muscle loss found in humans using clinically relevant modes of injury. Clinically, understanding the mechanics and underlying biology of the muscle will impact both surgical decision-making and rehabilitation protocols, as interventions that may be good for atrophic muscle will have a detrimental effect on degenerating muscle, and vice versa.
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