Bacteriophage t4 nanoparticles as materials in sensor applications: variables that influence their organization and assembly on surfaces.
Bacteriophage t4 nanoparticles as materials in sensor applications: variables that influence their organization and assembly on surfaces.
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DOI:
10.3390/s90806298
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发表时间:
2009
期刊:
影响因子:
--
通讯作者:
Liu JL
中科院分区:
文献类型:
--
作者:
Archer MJ;Liu JL
Bacteriophage T4 nanoparticles possess characteristics that make them ideal candidates as materials for sensors, particularly as sensor probes. Their surface can be modified, either through genetic engineering or direct chemical conjugation to display functional moieties such as antibodies or other proteins to recognize a specific target. However, in order for T4 nanoparticles to be utilized as a sensor probe, it is necessary to understand and control the variables that determine their assembly and organization on a surface. The aim of this work is to discuss some of variables that we have identified as influencing the behavior of T4 nanoparticles on surfaces. The effect of pH, ionic strength, substrate characteristics, nanoparticle concentration and charge was addressed qualitatively using atomic force microscopy (AFM).
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