Effect of the cortex on ultrasonic backscatter measurements of cancellous bone.
Effect of the cortex on ultrasonic backscatter measurements of cancellous bone.
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DOI：
10.1088/0031-9155/56/19/006
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发表时间：
2011-10-07
影响因子：
3.5
通讯作者：
Kaste SC
中科院分区：
文献类型：
--
作者：
Hoffmeister BK;Holt AP;Kaste SC
超声背向散射技术为检测骨质疏松症引起的骨变化提供了一种有前途的新方法。然而，一些挑战阻碍了反向散射技术的临床实施。本研究探讨了骨（皮质）的致密外表面如何影响多孔（松质）骨组织内部区域的后向散射测量。从13个人股骨头制备了52个骨样本，以便通过皮质或沿着避开皮质的方向超声询问松质骨的相同区域。在0.8-3.0 MHz的频率范围内分析背向散射信号，以确定两个超声参数：表观背向散射积分（AIB）和表观背向散射频率斜率（FSAB）。术语“表观”是指参数对衍射和衰减的频率相关效应敏感。AIB和FSAB的显著变化（p < 0.001）表明，通过皮层的测量降低了表观后向散射功率，并增加了功率的频率依赖性。然而，皮质并不影响AIB和FSAB与标本的X线骨密度的相关性。这表明，从许多以前的纯松质骨标本的体外背散射研究的结果可以外推在体内条件下具有更大的信心。
Ultrasonic backscatter techniques offer a promising new approach for detecting changes in bone caused by osteoporosis. However, several challenges impede clinical implementation of backscatter techniques. This study examines how the dense outer surface of bone (the cortex) affects backscatter measurements of interior regions of porous (cancellous) bone tissue. Fifty-two specimens of bone were prepared from 13 human femoral heads so that the same region of cancellous bone could be ultrasonically interrogated through the cortex or along directions that avoided the cortex. Backscatter signals were analyzed over a frequency range of 0.8-3.0 MHz to determine two ultrasonic parameters: apparent integrated backscatter (AIB) and frequency slope of apparent backscatter (FSAB). The term “apparent” means that the parameters are sensitive to the frequency dependent effects of diffraction and attenuation. Significant (p < 0.001) changes in AIB and FSAB indicated that measurements through the cortex decreased the apparent backscattered power and increased the frequency dependence of the power. However, the cortex did not affect the correlation of AIB and FSAB with the x-ray bone mineral density of the specimens. This suggests that results from many previous in vitro backscatter studies of specimens of purely cancellous bone may be extrapolated with greater confidence to in vivo conditions.
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影响因子：
2.4
作者：
MADSEN, EL;INSANA, MF;ZAGZEBSKI, JA
通讯作者：
ZAGZEBSKI, JA
影响因子：
2.4
作者：
SIGELMANN, RA;REID, JM
通讯作者：
REID, JM
影响因子：
2.4
作者：
WEAR, KA;MILUNSKI, MR;MILLER, JG
通讯作者：
MILLER, JG
DOI：
10.1109/tuffc.2008.819
发表时间：
2008-07-01
影响因子：
3.6
作者：
Hoffmeister, Brent K.;Johnson, David P.;Kaste, Sue C.
通讯作者：
Kaste, Sue C.
影响因子：
4
作者：
Hoffmeister, BK;Whitten, SA;Rho, JY
通讯作者：
Rho, JY