Glypicans.
Glypicans.
复制标题
DOI：
10.1186/gb-2008-9-5-224
复制
发表时间：
2008
期刊：
影响因子：
12.3
通讯作者：
Rast J
中科院分区：
文献类型：
--
作者：
Filmus J;Capurro M;Rast J
磷脂酰肌醇蛋白聚糖家族的细胞表面硫酸乙酰肝素蛋白聚糖调节许多发育重要的信号蛋白的行动。 磷脂酰肌醇蛋白聚糖是通过糖基-磷脂酰肌醇锚结合到质膜外表面的硫酸乙酰肝素蛋白聚糖。在真后生动物中发现了Glypicans的同源物。在哺乳动物中有六个家族成员（GPC 1至GPC 6）。磷脂酰肌醇蛋白聚糖可以通过称为Notum的脂肪酶从细胞表面释放，并且它们中的大多数受到弗林蛋白酶样转化酶的内切蛋白水解切割。迄今为止发表的体内证据表明，膜附着磷脂酰肌醇蛋白聚糖的主要功能是调节Wnt、Hedgehog、成纤维细胞生长因子和骨形态发生蛋白（BMP）的信号传导。根据上下文，磷脂酰肌醇蛋白聚糖可对信号传导具有刺激或抑制活性。在Wnt的情况下，已经提出刺激机制是基于磷脂酰肌醇蛋白聚糖促进和/或稳定Wnt与其信号传导受体（卷曲蛋白）相互作用的能力。另一方面，最近报道GPC 3通过与Hedgehog受体Patched竞争Hedgehog结合来抑制发育期间的Hedgehog蛋白信号传导。令人惊讶的是，磷脂酰肌醇蛋白聚糖在Wnt、Hedgehog和BMP信号传导途径中的调节活性仅部分依赖于硫酸乙酰肝素链。
The glypican family of cell-surface heparan sulfate proteoglycans modulate the actions of many developmentally important signal proteins. Glypicans are heparan sulfate proteoglycans that are bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor. Homologs of glypicans are found throughout the Eumetazoa. There are six family members in mammals (GPC1 to GPC6). Glypicans can be released from the cell surface by a lipase called Notum, and most of them are subjected to endoproteolytic cleavage by furin-like convertases. In vivo evidence published so far indicates that the main function of membrane-attached glypicans is to regulate the signaling of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs). Depending on the context, glypicans may have a stimulatory or inhibitory activity on signaling. In the case of Wnt, it has been proposed that the stimulatory mechanism is based on the ability of glypicans to facilitate and/or stabilize the interaction of Wnts with their signaling receptors, the Frizzled proteins. On the other hand, GPC3 has recently been reported to inhibit Hedgehog protein signaling during development by competing with Patched, the Hedgehog receptor, for Hedgehog binding. Surprisingly, the regulatory activity of glypicans in the Wnt, Hedgehog and BMP signaling pathways is only partially dependent on the heparan sulfate chains.
登录
查看更多内容
影响因子：
7.8
作者：
Ai, Xingbin;Do, Anh-Tri;Lozynska, Olga;Kusche-Gullberg, Marion;Lindahl, Ulf;Emerson, Charles P Jr
通讯作者：
Emerson, Charles P Jr
影响因子：
11.8
作者：
Kreuger, J;Perez, L;Cohen, SM
通讯作者：
Cohen, SM
影响因子：
4.6
作者：
Desbordes, SC;Sanson, B
通讯作者：
Sanson, B
影响因子：
64.5
作者：
Belenkaya, TY;Han, C;Lin, XH
通讯作者：
Lin, XH
影响因子：
11.8
作者：
Capurro, Mariana I.;Xu, Ping;Filmus, Jorge
通讯作者：
Filmus, Jorge