Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity.
Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity.
复制标题
下丘脑星形胶质细胞作为肥胖症的特化和反应性细胞群。
DOI：
10.3390/ijms22126176
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发表时间：
2021-06-08
影响因子：
5.6
通讯作者：
García-Cáceres C
中科院分区：
文献类型：
--
作者：
González-García I;García-Cáceres C
星形胶质细胞是一类神经胶质细胞，在解剖学和功能上整合到神经元调节回路中，用于神经内分泌控制代谢。作为突触的功能性组成化合物，星形胶质细胞积极参与代谢控制的生理调节方面，但也参与将神经元功能障碍和肥胖联系起来的病理过程。在大脑区域之间，下丘脑拥有专门的功能回路，这些回路似乎选择性地容易受到代谢损伤，经历早期细胞重排，这被认为是饮食诱导的肥胖症发病机制的核心。下丘脑脑区的这种变化包括促炎细胞因子的升高、星形胶质细胞和小胶质细胞中反应性表型的存在、下丘脑回路的细胞结构和突触学的改变以及血管生成，这是大脑其他地方无法发现的现象。越来越多的证据表明，下丘脑星形胶质细胞直接参与这种早期代谢紊乱，从而将这些神经胶质细胞的研究推向了肥胖研究的前沿。在这里，我们提供了一个全面的审查最相关的分子和病理生理机制的发现，下丘脑星形胶质细胞可能参与肥胖的发病机制。
Astrocytes are a type of glial cell anatomically and functionally integrated into the neuronal regulatory circuits for the neuroendocrine control of metabolism. Being functional integral compounds of synapses, astrocytes are actively involved in the physiological regulatory aspects of metabolic control, but also in the pathological processes that link neuronal dysfunction and obesity. Between brain areas, the hypothalamus harbors specialized functional circuits that seem selectively vulnerable to metabolic damage, undergoing early cellular rearrangements which are thought to be at the core of the pathogenesis of diet-induced obesity. Such changes in the hypothalamic brain region consist of a rise in proinflammatory cytokines, the presence of a reactive phenotype in astrocytes and microglia, alterations in the cytoarchitecture and synaptology of hypothalamic circuits, and angiogenesis, a phenomenon that cannot be found elsewhere in the brain. Increasing evidence points to the direct involvement of hypothalamic astrocytes in such early metabolic disturbances, thus moving the study of these glial cells to the forefront of obesity research. Here we provide a comprehensive review of the most relevant findings of molecular and pathophysiological mechanisms by which hypothalamic astrocytes might be involved in the pathogenesis of obesity.
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影响因子：
8.1
作者：
Buckman LB;Thompson MM;Lippert RN;Blackwell TS;Yull FE;Ellacott KL
通讯作者：
Ellacott KL
影响因子：
64.5
作者：
García-Cáceres C;Quarta C;Varela L;Gao Y;Gruber T;Legutko B;Jastroch M;Johansson P;Ninkovic J;Yi CX;Le Thuc O;Szigeti-Buck K;Cai W;Meyer CW;Pfluger PT;Fernandez AM;Luquet S;Woods SC;Torres-Alemán I;Kahn CR;Götz M;Horvath TL;Tschöp MH
通讯作者：
Tschöp MH
DOI：
10.1016/j.ecl.2012.11.003
发表时间：
2013-03-01
影响因子：
4.5
作者：
Garcia-Caceres, Cristina;Yi, Chun-Xia;Tschoep, Matthias H.
通讯作者：
Tschoep, Matthias H.
影响因子：
6.2
作者：
Hernandez-Garzon, Edwin;Fernandez, Ana M.;Torres Aleman, Ignacio
通讯作者：
Torres Aleman, Ignacio
影响因子：
2.8
作者：
Arluison, M;Quignon, M;Penicaud, L
通讯作者：
Penicaud, L