The role of the central noradrenergic system in behavioral inhibition.
The role of the central noradrenergic system in behavioral inhibition.
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DOI：
10.1016/j.brainresrev.2011.02.002
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发表时间：
2011-06-24
影响因子：
--
通讯作者：
Quartermain D
中科院分区：
文献类型：
--
作者：
Stone EA;Lin Y;Sarfraz Y;Quartermain D
虽然中枢去甲肾上腺素系统已经被证明参与了许多行为和神经生理过程，但这些过程与其在抑郁症中的作用的关系一直很难确定。本综述讨论了一种假说，即它的主要功能之一可能与情感性疾病有关，即抑制行为激活，这是该疾病的一个突出症状。这一假说被发现与以前大多数关于啮齿动物主动行为的神经心理药理学和免疫组织化学实验是一致的，在各种实验条件下，通过操纵蓝斑和前脑肾上腺素能受体的神经传递。这一发现支持了一种机制，即高比率的去甲肾上腺素能神经活动抑制了前脑区域主神经元的神经活动，这些区域介导了活跃的行为。这种抑制可能是通过突触后的甘氨酸能和肾上腺素能受体，以及通过释放促肾上腺皮质激素来实现的。这一假说与抑郁症患者中枢去甲肾上腺素系统过度活动的临床证据是一致的，也与这种过度活动是导致这种疾病的病因因素的观点一致。类似的机制可能是去甲肾上腺素系统抑制癫痫发作的能力的基础，这表明抑制神经激活的扩散可能是一种统一的功能。
Although the central noradrenergic system has been shown to be involved in a number of behavioral and neurophysiological processes, the relation of these to its role in depressive illness has been difficult to define. The present review discusses the hypothesis that one of its chief functions that may be related to affective illness is the inhibition of behavioral activation, a prominent symptom of the disorder. This hypothesis is found to be consistent with most previous neuropsychopharmacological and immunohistochemical experiments on active behavior in rodents in a variety of experimental conditions using manipulation of neurotransmission at both locus coeruleus and forebrain adrenergic receptors. The findings support a mechanism in which high rates of noradrenergic neural activity suppress the neural activity of principal neurons in forebrain regions mediating active behavior. The suppression may be mediated through postsynaptic galaninergic and adrenergic receptors, and via the release of corticotrophin-releasing hormone. The hypothesis is consistent with clinical evidence for central noradrenergic system hyperactivity in depressives and with the view that this hyperactivity is a contributing etiological factor in the disorder. A similar mechanism may underlie the ability of the noradrenergic system to suppress seizure activity suggesting that inhibition of the spread of neural activation may be a unifying function.
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影响因子：
6.1
作者：
BORSINI, F;NOWAKOWSKA, E;SAMANIN, R
通讯作者：
SAMANIN, R
影响因子：
3.3
作者：
Aono, Y.;Saigusa, T.;Cools, A. R.
通讯作者：
Cools, A. R.
影响因子：
5.5
作者：
Carr, David B.;Andrews, Glenn D.;Lavin, A.
通讯作者：
Lavin, A.
影响因子：
4.7
作者：
BARABAN, JM;AGHAJANIAN, GK
通讯作者：
AGHAJANIAN, GK
影响因子：
--
作者：
BECKMAN, AL;SATINOFF, E
通讯作者：
SATINOFF, E