Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development.
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development.
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Runx蛋白和调控记忆性CD8 T细胞发育的转录机制
DOI：
10.1111/imr.12954
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发表时间：
2021-03
影响因子：
8.7
通讯作者：
中科院分区：
文献类型：
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作者：
对细胞内病原体和肿瘤的适应性免疫是由经历过抗原的CD8T细胞介导的。单个单纯的CD8 T细胞有可能分化为不同的抗原经验亚群，这些亚群具有不同的效应功能、寿命、解剖定位和在反复致病暴露期间再生全新免疫反应的潜力。激活的幼稚细胞经历多样化的发育过程涉及染色质结构和转录的调节，但尚不完全清楚。本文就染色质结构、转录因子结合、细胞外信号和单细胞基因表达的变化如何解释感染后不同的效应(TEFF)和记忆(TMEM)CD8T细胞亚群的不同发育进行了综述。特别强调RUNX蛋白如何与其他转录因子一起发挥作用，以引领染色质可及性的变化，并驱动转录程序，这些程序建立细胞毒性T淋巴细胞的核心属性，细分循环和非循环TMEM细胞亚群，并控制末端分化。该讨论整合了特定细胞因子信号、转录回路的作用，以及个体核小体和RNA聚合酶II活性的调节如何有助于分化过程。本文讨论了一个集成了许多这些特征的模型，以概念化激活的CD8 T细胞如何到达它们的命运。
Adaptive immunity to intracellular pathogens and tumors is mediated by antigen-experienced CD8 T cells. Individual naïve CD8 T cells have the potential to differentiate into a diverse array of antigen-experienced subsets that exhibit distinct effector functions, life-spans, anatomic positioning and potential for regenerating an entirely new immune response during iterative pathogenic exposures. The developmental process by which activated naïve cells undergo diversification involves regulation of chromatin structure and transcription but is not entirely understood. This review examines how alterations in chromatin structure, transcription factor binding, extracellular signals and single cell gene expression explain the differential development of distinct effector (TEFF) and memory (TMEM) CD8 T cell subsets that arise after infections. Special emphasis is placed on how Runx-proteins function with additional transcription factors to pioneer changes in chromatin accessibility and drive transcriptional programs that establish the core attributes of cytotoxic T lymphocytes, subdivide circulating and non-circulating TMEM cell subsets, and govern terminal differentiation. The discussion integrates the roles of specific cytokine signals, transcriptional circuits and how regulation of individual nucleosomes and RNA Polymerase II activity can contribute to the process of differentiation. A model that integrates many of these features is discussed to conceptualize how activated CD8 T cells arrive at their fates.
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DOI：
10.15252/embj.201592534
发表时间：
2016-03-01
期刊：
The EMBO journal
影响因子：
--
作者：
Bevington SL;Cauchy P;Piper J;Bertrand E;Lalli N;Jarvis RC;Gilding LN;Ott S;Bonifer C;Cockerill PN
通讯作者：
Cockerill PN
影响因子：
16
作者：
Calo, Eliezer;Wysocka, Joanna
通讯作者：
Wysocka, Joanna
影响因子：
64.8
作者：
Brogaard, Kristin;Xi, Liqun;Wang, Ji-Ping;Widom, Jonathan
通讯作者：
Widom, Jonathan
影响因子：
7.3
作者：
Bevington SL;Cauchy P;Withers DR;Lane PJ;Cockerill PN
通讯作者：
Cockerill PN
影响因子：
30.5
作者：
通讯作者：
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