Trade‐offs in defence to pathogen species revealed in expanding nematode populations
Trade‐offs in defence to pathogen species revealed in expanding nematode populations
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线虫种群扩张揭示了防御病原体物种的权衡
DOI：
10.1111/jeb.14023
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发表时间：
2022
影响因子：
2.1
通讯作者：
King, Kayla C.
中科院分区：
文献类型：
--
作者：
Ordovás‐Montañés, María;Preston, Gail M.;Hoang, Kim L.;Rafaluk‐Mohr, Charlotte;King, Kayla C.
许多宿主生物生活在多微生物环境中，必须对多种病原体做出反应。宿主对一种病原体的防御在多大程度上影响对其他病原体的易感性尚不清楚。我们使用一组秀丽隐杆线虫线虫分离株来测试免疫上调和病原体损伤的适应性成本的自然遗传变异，以及防御两种病原体物种金黄色葡萄球菌和铜绿假单胞菌的权衡。我们通过测量宿主种群的大小来检查瞬时病原体暴露（病原体损伤和免疫上调）或暴露于热灭活培养物（仅免疫上调）的适应性影响，这使我们能够同时捕获生殖输出，发育时间和存活率的变化。我们发现，暴露于活的与热灭活的S的宿主的种群规模显着下降。金黄色葡萄球菌，并发现与相应的热灭活挑战相比，活铜绿假单胞菌暴露后的生殖输出增加。在活的铜绿假单胞菌感染后，具有相对较高种群大小的线虫分离株在活的S.金黄色葡萄球菌攻击。这些结果表明，野生C。线虫基因型显示权衡防御两种不同的病原体物种，在随后的generations.AbstractMany生物体生活在环境中，他们暴露于多种病原体。我们使用了一组野生秀丽隐杆线虫分离株来测试两种病原体物种的自然遗传变异。我们发现宿主基因型在防御两种病原体方面存在权衡，并对后代产生影响。
Many host organisms live in polymicrobial environments and must respond to a diversity of pathogens. The degree to which host defences towards one pathogen species affect susceptibility to others is unclear. We used a panel of Caenorhabditis elegans nematode isolates to test for natural genetic variation in fitness costs of immune upregulation and pathogen damage, as well as for trade‐offs in defence against two pathogen species, Staphylococcus aureus and Pseudomonas aeruginosa. We examined the fitness impacts of transient pathogen exposure (pathogen damage and immune upregulation) or exposure to heat‐killed culture (immune upregulation only) by measuring host population sizes, which allowed us to simultaneously capture changes in reproductive output, developmental time and survival. We found significant decreases in population sizes for hosts exposed to live versus heat‐killed S. aureus and found increased reproductive output after live P. aeruginosa exposure, compared with the corresponding heat‐killed challenge. Nematode isolates with relatively higher population sizes after live P. aeruginosa infection produced fewer offspring after live S. aureus challenge. These findings reveal that wild C. elegans genotypes display a trade‐off in defences against two distinct pathogen species that are evident in subsequent generations.AbstractMany organisms live in environments where they are exposed to a diversity of pathogens. We used a panel of wildCaenorhabditis elegansnematode isolates to test for natural genetic variation in response to two pathogen species. We found host genotypes traded‐off in defence against the two pathogens with impacts on subsequent generations.
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DOI：
10.1038/ismej.2015.259
发表时间：
2016-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.4
作者：
Schulenburg, H;Müller, S
通讯作者：
Müller, S
影响因子：
11.4
作者：
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通讯作者：
Andersen, Erik C.
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DOI：
10.1101/2020.08.26.262683
发表时间：
2020
期刊：
Proceedings of the National Academy of Sciences
影响因子：
--
作者：
V. Ezenwa;S. Budischak;P. Buss;M. Seguel;G. Luikart;A. Jolles;K. Sakamoto
通讯作者：
K. Sakamoto
影响因子：
5.4
作者：
Dirksen P;Marsh SA;Braker I;Heitland N;Wagner S;Nakad R;Mader S;Petersen C;Kowallik V;Rosenstiel P;Félix MA;Schulenburg H
通讯作者：
Schulenburg H