Body mass index-related human adipocyte agouti expression is sex-specific but not depot-specific.
Body mass index-related human adipocyte agouti expression is sex-specific but not depot-specific.
复制标题
体重指数相关的人类脂肪细胞刺鼠表达具有性别特异性，但不具有储存特异性。
DOI：
10.1038/oby.2002.62
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
A. van Daal
中科院分区：
文献类型：
--
作者：
J. Voisey;P. Imbeault;L. Hutley;J. Prins;A. van Daal
客观的
OBJECTIVE
To determine if human adipocyte agouti signal protein (ASIP) mRNA expression is associated with obesity and is gender and/or depot specific.
RESEARCH METHODS AND PROCEDURES
Subjects included 8 men (64 +/- 3 years) and 14 women (56 +/- 15 years) undergoing elective abdominal surgery. ASIP mRNA levels in isolated omental and subcutaneous abdominal adipocytes were measured by quantitative reverse transcription polymerase chain reaction.
RESULTS
No significant depot difference was observed between genders; ASIP mRNA levels of omental and subcutaneous abdominal adipocytes were pooled for this analysis. BMI and ASIP gene expression were negatively correlated in men (rho = -0.70; p < 0.05), whereas a positive relationship was observed in women (rho = 0.48; p < 0.05). No significant difference was observed in age, body weight, body mass index (BMI), and waist circumference between groups. Hip circumference was significantly higher in women than in men (p < 0.05). Also, no significant difference in ASIP mRNA expression was observed between men and women, regardless of the fat depot.
DISCUSSION
These results show that men and women of similar age and BMI present similar ASIP mRNA levels in omental and subcutaneous abdominal adipocytes. However, a sexual dimorphism exists in the relationship between ASIP expression and BMI. If ASIP is involved in appetite regulation or energy homeostasis in humans, this observation may contribute to the recognized differences in these parameters between men and women.
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使用 ASP 特异性抗体进行免疫组织化学，对小鼠皮肤中刺鼠信号蛋白进行原位定位。
影响因子：
3.1
作者：
Matsunaga,N;Virador,V;Santis,C;Vieira,WD;Furumura,M;Matsunaga,J;Kobayashi,N;Hearing,VJ
通讯作者：
Hearing,VJ
小鼠致死性黄色 (Ay) 突变的多效性效应可以通过删除母源表达基因和同时产生刺豚鼠融合 RNA 来解释。
DOI：
10.1242/dev.120.6.1695
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Duhl,DM;Stevens,ME;Vrieling,H;Saxon,PJ;Miller,MW;Epstein,CJ;Barsh,GS
通讯作者：
Barsh,GS
DOI：
10.1210/jcem.81.11.8923837
发表时间：
1996-11
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
通讯作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
DOI：
10.1073/pnas.91.21.9760
发表时间：
1994-10-11
影响因子：
11.1
作者：
KWON, HY;BULTMAN, SJ;WOYCHIK, RP
通讯作者：
WOYCHIK, RP
影响因子：
10.5
作者：
MICHAUD, EJ;BULTMAN, SJ;WOYCHIK, RP
通讯作者：
WOYCHIK, RP