Real-time ultrasound angiography using superharmonic dual-frequency (2.25MHz/30MHz) cylindrical array: In vitro study.
Real-time ultrasound angiography using superharmonic dual-frequency (2.25MHz/30MHz) cylindrical array: In vitro study.
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DOI：
10.1016/j.ultras.2017.09.012
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发表时间：
2018-01
期刊：
影响因子：
4.2
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Wang Z;Martin KH;Dayton PA;Jiang X
最近的研究表明，双频血管内超声（IVUS）换能器允许检测超谐波气泡签名，使微血管和分子成像的声学血管造影术。本文研制了一种用于实时超谐波成像的双频IVUS圆柱阵探头。使用减小形状因子的横向模式发射器（2.25MHz）在782 kPa下以单循环激发有效地激发微泡，同时仍然保持用于血管内成像应用的小尺寸和低轮廓（5 Fr）（3Fr = 1 mm）。在模拟微血管中产生的超谐波微泡响应由高频接收器（30 MHz）捕获。在直径为200 µ m的纤维素管中，测得微泡的轴向和侧向半高宽分别为162 µm和1039 µm，对比噪声比（CNR）为16.6 dB。与我们之前报道的单元件IVUS探头相比，该IVUS阵列设计实现了更高的CNR（16.6 dB vs 11 dB）和更高的轴向分辨率（162 µm vs 616 µm）。结果表明，这种具有横向模式发射器的双频IVUS阵列换能器可以通过产生非线性微泡响应以及检测它们在5 Fr形状因子中的超谐波响应来满足声学血管造影的本地设计要求（~3-5 Fr）。
Recent studies suggest that dual-frequency intravascular ultrasound (IVUS) transducers allow detection of superharmonic bubble signatures, enabling acoustic angiography for microvascular and molecular imaging. In this paper, a dual-frequency IVUS cylindrical array transducer was developed for real-time superharmonic imaging. A reduced form-factor lateral mode transmitter (2.25 MHz) was used to excite microbubbles effectively at 782 kPa with single-cycle excitation while still maintaining the small size and low profile (5 Fr) (3 Fr = 1 mm) for intravascular imaging applications. Superharmonic microbubble responses generated in simulated microvessels were captured by the high frequency receiver (30 MHz). The axial and lateral full-width half-maximum of microbubbles in a 200-µm-diameter cellulose tube were measured to be 162 µm and 1039 µm, respectively, with a contrast-to-noise ratio (CNR) of 16.6 dB. Compared to our previously reported single-element IVUS transducers, this IVUS array design achieves a higher CNR (16.6 dB vs 11 dB) and improved axial resolution (162 µm vs 616 µm). The results show that this dual-frequency IVUS array transducer with a lateral-mode transmitter can fulfill the native design requirement (~3–5 Fr) for acoustic angiography by generating nonlinear microbubble responses as well as detecting their superharmonic responses in a 5 Fr form factor.
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影响因子：
7.6
作者：
Gessner RC;Frederick CB;Foster FS;Dayton PA
通讯作者：
Dayton PA
DOI：
10.1109/tuffc.2014.006466
发表时间：
2014-10
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
--
作者：
Lindsey BD;Rojas JD;Martin KH;Shelton SE;Dayton PA
通讯作者：
Dayton PA
DOI：
10.1109/tuffc.2014.2977
发表时间：
2014-05-01
影响因子：
3.6
作者：
Ma, Jianguo;Martin, K. Heath;Jiang, Xiaoning
通讯作者：
Jiang, Xiaoning
影响因子：
14
作者：
Staub, Daniel;Schinkel, Arend F. L.;Feinstein, Steven B.
通讯作者：
Feinstein, Steven B.
影响因子：
4.2
作者：
Kim, Jinwook;Li, Sibo;Jiang, Xiaoning
通讯作者：
Jiang, Xiaoning