Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?
Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?
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DOI：
10.3389/fimmu.2014.00470
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发表时间：
2014
影响因子：
7.3
通讯作者：
Kammoun HL
中科院分区：
文献类型：
--
作者：
Kraakman MJ;Murphy AJ;Jandeleit-Dahm K;Kammoun HL
肥胖和2型糖尿病现在被认为是慢性促炎性疾病。在过去的十年里，巨噬细胞的作用在它们的发病机制中变得越来越重要。大量文献表明，单核细胞被募集到外周组织(如胰腺、肝脏和脂肪组织)，成为常驻巨噬细胞，并有助于局部炎症、胰岛素抵抗的发展，甚至胰腺功能障碍。此外，越来越多的证据表明巨噬细胞极化在代谢性疾病的发展中起着重要作用。肥胖症的一般观点是M1/M2巨噬细胞比例失衡，与M2“抗炎”巨噬细胞相比，M1“促炎”巨噬细胞增强，导致慢性炎症和代谢功能障碍的传播。然而，新出现的证据揭示了一种更复杂的情况，巨噬细胞状态的谱远远超出了M1/M2的二进制分类，并进一步被表现出不同巨噬细胞谱的人类和动物模型所混淆。在这篇综述中，我们将讨论有关肥胖症和2型糖尿病中巨噬细胞极化的最新发现。
Obesity and type 2 diabetes are now recognized as chronic pro-inflammatory diseases. In the last decade, the role of the macrophage in particular has become increasingly implicated in their pathogenesis. Abundant literature now establishes that monocytes get recruited to peripheral tissues (i.e., pancreas, liver, and adipose tissue) to become resident macrophages and contribute to local inflammation, development of insulin resistance, or even pancreatic dysfunction. Furthermore, an accumulation of evidence has established an important role for macrophage polarization in the development of metabolic diseases. The general view in obesity is that there is an imbalance in the ratio of M1/M2 macrophages, with M1 “pro-inflammatory” macrophages being enhanced compared with M2 “anti-inflammatory” macrophages being down-regulated, leading to chronic inflammation and the propagation of metabolic dysfunction. However, there is emerging evidence revealing a more complex scenario with the spectrum of macrophage states exceeding well beyond the M1/M2 binary classification and confused further by human and animal models exhibiting different macrophage profiles. In this review, we will discuss the recent findings regarding macrophage polarization in obesity and type 2 diabetes.
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影响因子：
64.8
作者：
Nguyen, Khoa D.;Qiu, Yifu;Cui, Xiaojin;Goh, Y. P. Sharon;Mwangi, Julia;David, Tovo;Mukundan, Lata;Brombacher, Frank;Locksley, Richard M.;Chawla, Ajay
通讯作者：
Chawla, Ajay
巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
影响因子：
20.1
作者：
Randolph GJ
通讯作者：
Randolph GJ
影响因子：
29
作者：
Nagareddy PR;Kraakman M;Masters SL;Stirzaker RA;Gorman DJ;Grant RW;Dragoljevic D;Hong ES;Abdel-Latif A;Smyth SS;Choi SH;Korner J;Bornfeldt KE;Fisher EA;Dixit VD;Tall AR;Goldberg IJ;Murphy AJ
通讯作者：
Murphy AJ
影响因子：
4.1
作者：
Fjeldborg K;Pedersen SB;Møller HJ;Christiansen T;Bennetzen M;Richelsen B
通讯作者：
Richelsen B