Optimizing odor identification testing as quick and accurate diagnostic tool for Parkinson's disease.
Optimizing odor identification testing as quick and accurate diagnostic tool for Parkinson's disease.
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DOI：
10.1002/mds.26637
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发表时间：
2016-09
影响因子：
8.6
通讯作者：
Seppi, Klaus
中科院分区：
文献类型：
--
作者：
Mahlknecht, Philipp;Pechlaner, Raimund;Boesveldt, Sanne;Volc, Dieter;Pinter, Bernardette;Reiter, Eva;Mueller, Christoph;Krismer, Florian;Berendse, Henk W.;van Hilten, Jacobus J.;Wuschitz, Albert;Schimetta, Wolfgang;Hoegl, Birgit;Djamshidian, Atbin;Nocker, Michael;Goebel, Georg;Gasperi, Arno;Kiechl, Stefan;Willeit, Johann;Poewe, Werner;Seppi, Klaus
本研究的目的是评估气味识别测试作为一种快速、廉价且可靠的 PD 识别工具。使用 16 项 Sniffin' Sticks 测试 (SS-16) 对来自三个欧洲中心（A、B 和 C）的 646 名 PD 患者和 606 名对照者、75 名非典型帕金森病或特发性震颤患者以及 24 名特发性快速眼动睡眠行为障碍患者（中心 A）的前瞻性队列进行了气味识别评估。对 PD 最具辨别力的减少气味组是在一个发现队列中确定的，该发现队列是使用 L1 正则化逻辑回归随机分割来自 A 中心的 PD 患者和对照组。作为验证队列，对其余患者/对照的诊断准确性进行了评估。在所有队列中，与对照组和非 PD 患者相比，PD 患者的嗅觉表现较低（每个 P < 0.001）。完整的 SS-16 和前八个辨别气味 (SS-8) 的子分数都与 PD 与对照组（曲线下面积≥0.90；敏感性≥83.3%；特异性≥82.0%）和非 PD 患者（曲线下面积≥0.91；敏感性≥84.1%；特异性≥84.0%）的良好区分相关。所有队列。当病程>3年的患者被排除在分析之外时，这一点保持不变。使用 SS-16 和 SS-8 预测特发性快速眼动睡眠行为障碍患者中的所有 8 例 PD 病例（敏感性，100%；阳性预测值，61.5%）。气味识别测试在区分 PD 患者与对照和诊断模拟患者方面提供了出色的诊断准确性。减少的八种气味可以用作帕金森病患者检查和帕金森病风险指示的快速工具。 © 2016 作者。 《运动障碍》由 Wiley periodicals, Inc. 代表国际帕金森和运动障碍协会出版
The aim of this study was to evaluate odor identification testing as a quick, cheap, and reliable tool to identify PD. Odor identification with the 16‐item Sniffin' Sticks test (SS‐16) was assessed in a total of 646 PD patients and 606 controls from three European centers (A, B, and C), as well as 75 patients with atypical parkinsonism or essential tremor and in a prospective cohort of 24 patients with idiopathic rapid eye movement sleep behavior disorder (center A). Reduced odor sets most discriminative for PD were determined in a discovery cohort derived from a random split of PD patients and controls from center A using L1‐regularized logistic regression. Diagnostic accuracy was assessed in the rest of the patients/controls as validation cohorts. Olfactory performance was lower in PD patients compared with controls and non‐PD patients in all cohorts (each P < 0.001). Both the full SS‐16 and a subscore of the top eight discriminating odors (SS‐8) were associated with an excellent discrimination of PD from controls (areas under the curve ≥0.90; sensitivities ≥83.3%; specificities ≥82.0%) and from non‐PD patients (areas under the curve ≥0.91; sensitivities ≥84.1%; specificities ≥84.0%) in all cohorts. This remained unchanged when patients with >3 years of disease duration were excluded from analysis. All 8 incident PD cases among patients with idiopathic rapid eye movement sleep behavior disorder were predicted with the SS‐16 and the SS‐8 (sensitivity, 100%; positive predictive value, 61.5%). Odor identification testing provides excellent diagnostic accuracy in the distinction of PD patients from controls and diagnostic mimics. A reduced set of eight odors could be used as a quick tool in the workup of patients presenting with parkinsonism and for PD risk indication. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
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影响因子：
8.6
作者：
Boesveldt, Sanne;Verbaan, Dagmar;Berendse, Henk W.
通讯作者：
Berendse, Henk W.
影响因子：
11
作者：
Ponsen, Mirthe M.;Stoffers, Diederick;Berendse, Henk W.
通讯作者：
Berendse, Henk W.
影响因子：
3.5
作者：
WENNING, GK;SHEPHARD, B;QUINN, N
通讯作者：
QUINN, N
影响因子：
4.1
作者：
Mahlknecht, Philipp;Kiechl, Stefan;Seppi, Klaus
通讯作者：
Seppi, Klaus
影响因子：
9.9
作者：
Mahlknecht, Philipp;Iranzo, Alex;Seppi, Klaus
通讯作者：
Seppi, Klaus