dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.
dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.
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DOI：
10.1016/j.devcel.2009.12.007
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发表时间：
2010-01-19
影响因子：
11.8
通讯作者：
Lee CY
中科院分区：
文献类型：
--
作者：
Weng M;Golden KL;Lee CY
为了确保正常发育和维持体内平衡，干细胞的广泛发育潜力必须在功能上与转运放大细胞的有限发育潜力区分开来。然而，人们对限制转运放大细胞发育潜力的机制知之甚少。在这里，我们表明，进化上保守的转录因子 dFezf/Earmuff (Erm) 能够细胞自主地发挥作用，以维持果蝇幼虫大脑中 II 型神经母细胞产生的中间神经祖细胞的受限发育潜力。尽管 erm 突变中间神经祖细胞被正确指定并显示出正常的顶端-基底皮层极性，但它们可以去分化回到神经母细胞状态，在功能上与正常 II 型神经母细胞没有区别。 Erm 通过激活 Prospero 来限制增殖并通过拮抗 Notch 信号传导来防止去分化，从而限制中间神经祖细胞的潜力。我们得出的结论是，Erm 依赖性在功能上区分果蝇幼虫大脑中的中间神经祖细胞和神经母细胞，平衡神经发生与干细胞维持。
To ensure normal development and maintenance of homeostasis, the extensive developmental potential of stem cells must be functionally distinguished from the limited developmental potential of transit amplifying cells. Yet the mechanisms that restrict the developmental potential of transit amplifying cells are poorly understood. Here we show that the evolutionarily conserved transcription factor dFezf/Earmuff (Erm) functions cell-autonomously to maintain the restricted developmental potential of the intermediate neural progenitors generated by type II neuroblasts in Drosophila larval brains. Although erm mutant intermediate neural progenitors are correctly specified and show normal apical-basal cortical polarity, they can dedifferentiate back into a neuroblast state, functionally indistinguishable from normal type II neuroblasts. Erm restricts the potential of intermediate neural progenitors by acti-vating Prospero to limit proliferation and by antagonizing Notch signaling to prevent dedifferentiation. We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0600337103
发表时间：
2006-03-28
影响因子：
11.1
作者：
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通讯作者：
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