Resting network plasticity following brain injury.

Resting network plasticity following brain injury.
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DOI:
10.1371/journal.pone.0008220
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发表时间:
2009-12-14
期刊:
影响因子:
3.7
通讯作者:
Biswal BB
Biswal BB
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Nakamura T;Hillary FG;Biswal BB

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本研究的目的是研究神经网络的性质,在不同的时间点,在恢复创伤性脑损伤(TBI),使用图论。在严重TBI后3个月和6个月对6名参与者进行了全脑fMRI信号拓扑特性分析。结果显示,网络属性的变化,包括程度分布的变化,降低整体强度的连接,并增加“小世界”从3个月至6个月后受伤。研究结果表明,在从损伤中恢复的过程中,网络连接的强度而不是数量减少,因此在恢复过程中,网络开始接近健康成年人中观察到的情况。这是第一个检查恢复过程中受损神经系统功能连接的数据。
The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased “small-worldness” from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.
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