Nicotine evoked efferent transmitter release onto immature cochlear inner hair cells.
Nicotine evoked efferent transmitter release onto immature cochlear inner hair cells.
复制标题
尼古丁引起传出递质释放到未成熟的耳蜗内毛细胞上。
DOI：
10.1152/jn.00097.2020
复制
发表时间：
2020
影响因子：
2.5
通讯作者：
Fuchs,PA
中科院分区：
文献类型：
--
作者：
Zhang,Y;Glowatzki,E;Roux,I;Fuchs,PA
Olivocochlear neurons make temporary cholinergic synapses on inner hair cells of the rodent cochlea in the first 2 to 3 wk after birth. Repetitive stimulation of these efferent neurons causes facilitation of evoked release and increased spontaneous release that continues for seconds to minutes. Presynaptic nicotinic acetylcholine receptors (nAChRs) are known to modulate neurotransmitter release from brain neurons. The present study explores the hypothesis that presynaptic nAChRs help to increase spontaneous release from efferent terminals on cochlear hair cells. Direct application of nicotine (which does not activate the hair cells’ α9α10-containing nAChRs) produces sustained efferent transmitter release, implicating presynaptic nAChRs in this response. The effect of nicotine was reduced by application of ryanodine that reduces release of calcium from intraterminal stores.NEW & NOTEWORTHYSensory organs exhibit spontaneous activity before the onset of response to external stimuli. Such activity in the cochlea is subject to modulation by cholinergic efferent neurons that directly inhibit sensory hair cells (inner hair cells). Those efferent neurons are themselves subject to various modulatory mechanisms. One such mechanism is positive feedback by released acetylcholine onto presynaptic nicotinic acetylcholine receptors causing further release of acetylcholine.
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DOI：
--
发表时间：
2004
影响因子：
11.1
作者：
L. Rüttiger;Matthias Sausbier;U. Zimmermann;Harald Winter;Claudia Braig;J. Engel;Martina Knirsch;C. Arntz;Patricia Langer;B. Hirt;Marcus Müller;I. Köpschall;M. Pfister;S. Münkner;K. Rohbock;I. Pfaff;A. Rüsch;P. Ruth;M. Knipper
通讯作者：
L. Rüttiger;Matthias Sausbier;U. Zimmermann;Harald Winter;Claudia Braig;J. Engel;Martina Knirsch;C. Arntz;Patricia Langer;B. Hirt;Marcus Müller;I. Köpschall;M. Pfister;S. Münkner;K. Rohbock;I. Pfaff;A. Rüsch;P. Ruth;M. Knipper
豚鼠耳蜗中α小白蛋白的分子克隆和表达。
DOI：
--
发表时间：
1995
期刊：
Brain Research. Molecular Brain Research
影响因子：
--
作者：
A. Soto;M. Cluzel;N. Renard;C. Ripoll;M. Lavigne;M. Eybalin;C. Hamel
通讯作者：
C. Hamel
哺乳动物内毛细胞负电位下 Ca2+ 独立激活 BKCa 通道
DOI：
--
发表时间：
2005
期刊：
Journal of Physiology
影响因子：
--
作者：
Henrike Thurm;B. Fakler;D. Oliver
通讯作者：
D. Oliver
影响因子：
16.2
作者：
Schmitz, F;Königstorfer, A;Südhof, TC
通讯作者：
Südhof, TC
影响因子：
5.5
作者：
KROS, CJ;CRAWFORD, AC
通讯作者：
CRAWFORD, AC