Weight Loss and Sleep, Current Evidence in Animal Models and Humans.

Weight Loss and Sleep, Current Evidence in Animal Models and Humans.
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DOI:
10.3390/nu15153431
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发表时间:
2023-08-03
期刊:
影响因子:
5.9
通讯作者:
Gnessi, Lucio
Gnessi, Lucio
中科院分区:
医学2区
文献类型:
--
作者:
Gangitano, Elena;Martinez-Sanchez, Noelia;Bellini, Maria Irene;Urciuoli, Irene;Monterisi, Stefania;Mariani, Stefania;Ray, David;Gnessi, Lucio

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睡眠是生存所必需的重要过程。在工业化国家,睡眠时间减少的趋势有所增加,同时肥胖症和糖尿病的发病率急剧增加。睡眠不足可能会增加肥胖、糖尿病和心血管疾病的风险,另一方面,肥胖与睡眠障碍有关,如阻塞性呼吸暂停疾病、失眠和白天过度嗜睡。睡眠和代谢紊乱是相互关联的;因此,识别参与睡眠调节和代谢稳态的生理和分子途径可以在改善个体的代谢健康方面发挥重要作用。旨在减轻体重的方法可以为心脏代谢风险和睡眠质量提供益处,这反过来又可以间接地决定个体的心脏代谢表型的改善。我们修订了关于减肥和睡眠的文献,重点关注可能在人类和动物模型中存在这种关系的机制和分子。
Sleep is a vital process essential for survival. The trend of reduction in the time dedicated to sleep has increased in industrialized countries, together with the dramatic increase in the prevalence of obesity and diabetes. Short sleep may increase the risk of obesity, diabetes and cardiovascular disease, and on the other hand, obesity is associated with sleep disorders, such as obstructive apnea disease, insomnia and excessive daytime sleepiness. Sleep and metabolic disorders are linked; therefore, identifying the physiological and molecular pathways involved in sleep regulation and metabolic homeostasis can play a major role in ameliorating the metabolic health of the individual. Approaches aimed at reducing body weight could provide benefits for both cardiometabolic risk and sleep quality, which indirectly, in turn, may determine an amelioration of the cardiometabolic phenotype of individuals. We revised the literature on weight loss and sleep, focusing on the mechanisms and the molecules that may subtend this relationship in humans as in animal models.
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