Assessment of Central Visual Function in Patients with Retinitis Pigmentosa.
Assessment of Central Visual Function in Patients with Retinitis Pigmentosa.
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DOI：
10.1038/s41598-018-26231-9
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发表时间：
2018-05-23
影响因子：
4.6
通讯作者：
Sonoda KH
中科院分区：
文献类型：
--
作者：
Fujiwara K;Ikeda Y;Murakami Y;Tachibana T;Funatsu J;Koyanagi Y;Nakatake S;Yoshida N;Nakao S;Hisatomi T;Yoshida S;Yoshitomi T;Ishibashi T;Sonoda KH
为了阐明色素性视网膜炎（RP）的疾病进展及其相关因素，需要有关RP中中央视功能变化的可靠数据。在这项纵向研究中，我们检查了 118 名被诊断为典型 RP 的患者。获得了视力 (VA)、使用带有中央 10-2 SITA 标准程序的汉弗莱视野分析仪的视野以及光学相干断层扫描测量。斜率源自通过线性混合模型为每只眼睛获得的平均偏差 (MD)、黄斑敏感度 (MS) 或中心凹敏感度 (FS) 的序列值，用于分析。 MS和FS分别计算为12个和4个中心点的平均视网膜敏感度。 MS 和 FS 斜率上的时间与中心子场厚度 (CST) 水平存在统计上显着的交互作用。与无黄斑并发症的眼睛相比，有黄斑并发症的眼睛具有更陡峭的MD、MS和FS斜率，并且这种交互作用不显着，但MS或FS斜率处于边缘趋势（分别P = 0.10、0.05）。计算出的中央视网膜敏感性（即MS和FS）斜率是RP中中央视功能进展的有效指标。
In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagnosed with typical RP. Visual acuity (VA), visual field using a Humphrey Field Analyzer with the central 10-2 SITA-Standard program, and optical coherence tomography measurements were obtained. The slopes, which were derived from serial values of mean deviation (MD), macular sensitivity (MS), or foveal sensitivity (FS) obtained for each eye by a linear mixed model, were used for analysis. MS and FS were calculated as the average retinal sensitivity of 12 and 4 central points respectively. There were statistically significant interactions of times with levels of the central subfield thickness (CST) on the slopes of MS and FS. Compared to the eyes without macular complications, the eyes with macular complications had steeper MD, MS and FS slopes, and this interaction was no significant, but marginal trend for the MS or FS slope (P = 0.10, 0.05, respectively). The central retinal sensitivity (i.e., MS and FS) slopes calculated were effective indices of the progression of central visual function in RP.
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影响因子：
4.6
作者：
Hasegawa T;Muraoka Y;Ikeda HO;Tsuruyama T;Kondo M;Terasaki H;Kakizuka A;Yoshimura N
通讯作者：
Yoshimura N
影响因子：
4.2
作者：
BERSON, EL;SANDBERG, MA;HANSON, AH
通讯作者：
HANSON, AH
影响因子：
5.1
作者：
Miyazaki, M;Ikeda, Y;Sueishi, K
通讯作者：
Sueishi, K
影响因子：
4.4
作者：
Iannaccone, A;Kritchevsky, SB;Somes, GW
通讯作者：
Somes, GW
影响因子：
4.4
作者：
Fujiwara, Kohta;Ikeda, Yasuhiro;Ishibashi, Tatsuro
通讯作者：
Ishibashi, Tatsuro