Nutritional Risk Index Predicts Survival in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy.
Nutritional Risk Index Predicts Survival in Patients With Breast Cancer Treated With Neoadjuvant Chemotherapy.
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营养风险指数 (NRI) 预测接受新辅助化疗的乳腺癌患者的生存期
DOI：
10.3389/fnut.2021.786742
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发表时间：
2021
影响因子：
5
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Chen L;Qi Y;Kong X;Su Z;Wang Z;Wang X;Du Y;Fang Y;Li X;Wang J
营养风险指数（NRI）是基于理想体重的指数，旨在呈现体重和血清白蛋白水平。它已被用来区分有术后并发症风险的患者并预测大型手术的术后结果。然而，对于接受新辅助化疗（NACT）治疗的乳腺癌患者来说，该指数仍然有限。该研究探讨了 NRI 对乳腺癌患者的临床和预后意义。这项回顾性研究纳入了 785 名乳腺癌患者（477 例接受了 NACT，308 例未接受）。通过受试者工作特征（ROC）曲线评估最佳NRI截止值，然后重新分类为低NRI组（<112）和高NRI组（≥112）。结果表明，NRI 通过单变量和多变量 Cox 回归生存分析独立预测无病生存期 (DFS) 和总生存期 (OS) [P = 0.019，风险比 (HR)：1.521，95% CI：1.071–2.161 和 P = 0.004，HR：1.415，95% CI：1.119–1.789； P = 0.026，HR：1.500，95% CI：1.051–2.143 且 P < 0.001，HR：1.547，95% CI：1.221–1.959]。根据NRI的最佳截止值，NRI值高的患者比NRI值低的患者具有更长的平均DFS和OS时间（63.47 vs. 40.50个月；71.50 vs. 56.39个月）。此外，结果表明，早期乳腺癌（χ2 = 9.0510，P = 0.0026和χ2 = 9.2140，P = 0.0024）和晚期乳腺癌（χ2 = 6.2500，P = 0.0124和χ2 = 5.8880）中，高NRI评分患者的平均DFS和OS时间显着长于低NRI评分患者。 P = 0.0152）。在不同分子亚型中，高 NRI 评分患者的平均 DFS 和 OS 值明显长于 NRI 评分低的患者。 NACT后常见的毒性是血液学和胃肠道反应，除了恶心（χ2 = 9.2413，P = 0.0024）、口腔溃疡（χ2 = 4.8133，P = 0.0282）、贫血（χ2 = 8.5441，P = 0.0140）和白细胞减少（χ2 = 11.0951，P = 0.0039）。 NRI作为一种微创、易于获取和方便的预后工具，用于评估乳腺癌的预后和治疗效果，并可以帮助医生选择更有效或更合适的措施来更好地治疗乳腺癌。
Nutritional risk index (NRI) is an index based on ideal body weight that aims to present body weight and serum albumin levels. It has been utilized to discriminate patients at risk of postoperative complications and predict the postoperative outcome of major surgeries. However, this index remains limited for breast cancer patients treated with neoadjuvant chemotherapy (NACT). The research explores the clinical and prognostic significance of NRI in breast cancer patients. This study included 785 breast cancer patients (477 cases received NACT and 308 cases did not) were enrolled in this retrospective study. The optimal NRI cutoff value was evaluated by receiver operating characteristic (ROC) curve, then reclassified as low NRI group (<112) and high NRI group (≥112). The results demonstrated that NRI independently predicted survival on disease-free survival (DFS) and overall survival (OS) by univariate and multivariate Cox regression survival analyses [P = 0.019, hazard ratio (HR): 1.521, 95% CI: 1.071–2.161 and P = 0.004, HR: 1.415, 95% CI: 1.119–1.789; and P = 0.026, HR:1.500, 95% CI: 1.051–2.143 and P < 0.001, HR: 1.547, 95% CI: 1.221–1.959]. According to the optimal cutoff value of NRI, the high NRI value patients had longer mean DFS and OS time in contrast to those with low NRI value patients (63.47 vs. 40.50 months; 71.50 vs. 56.39 months). Furthermore, the results demonstrated that the high NRI score patients had significantly longer mean DFS and OS time than those with low NRI score patients in early-stage breast cancer (χ2 = 9.0510, P = 0.0026 and χ2 = 9.2140, P = 0.0024) and advanced breast cancer (χ2 = 6.2500, P = 0.0124 and χ2 = 5.8880, P = 0.0152). The mean DFS and OS values in patients with high NRI scores were significantly longer in contrast to those with low NRI scores in different molecular subtypes. The common toxicities after NACT were hematologic and gastrointestinal reactions, and the NRI had no statistically significant effects on toxicities, except in nausea (χ2 = 9.2413, P = 0.0024), mouth ulcers (χ2 = 4.8133, P = 0.0282), anemia (χ2 = 8.5441, P = 0.0140), and leukopenia (χ2 = 11.0951, P = 0.0039). NRI serves as a minimally invasive, easily accessible and convenient prognostic tool for evaluating breast cancer prognoses and treatment efficacy, and may help doctors in terms of selecting measures of greater efficiency or appropriateness to better treat breast cancer.
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DOI：
10.1200/edbk_209183
发表时间：
2018-05-23
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Barrios, Carlos H;Reinert, Tomas;Werutsky, Gustavo
通讯作者：
Werutsky, Gustavo
影响因子：
3.7
作者：
Bo Y;Wang K;Liu Y;You J;Cui H;Zhu Y;Lu Q;Yuan L
通讯作者：
Yuan L
基于营养风险指数的男性和女性心脏移植患者的生存和营养状况。
影响因子：
5.9
作者：
Almutawa DA;Almuammar M;Elshafie MM;Aljuraiban GS;Alnafisah A;Abulmeaty MMA
通讯作者：
Abulmeaty MMA
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
DOI：
10.31744/einstein_journal/2020ao5075
发表时间：
2020-01-01
期刊：
Einstein (São Paulo)
影响因子：
--
作者：
Viana, Ana Carolina Cavalcante;Aguiar, Ana Patrícia Nogueira;Maia, Fernanda Maria Machado
通讯作者：
Maia, Fernanda Maria Machado