Relation of Overweight/Obesity to Reward Region Response to Food Reward and the Moderating Effects of Parental History of Eating Pathology in Adolescent Females.
Relation of Overweight/Obesity to Reward Region Response to Food Reward and the Moderating Effects of Parental History of Eating Pathology in Adolescent Females.
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DOI：
10.3390/nu15112558
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发表时间：
2023-05-30
期刊：
影响因子：
5.9
通讯作者：
Stice E
中科院分区：
文献类型：
--
作者：
Yokum S;Stice E
目的：测试超重/肥胖是否与对奶昔提示的奖赏区域反应升高和对奶昔接收的奖赏区域反应低相关。为了测试进食病理的风险是否缓和了体重状况对神经对奶昔提示和奶昔收据的反应的影响。方法：本研究应用功能磁共振成像(FMRI)技术检测了80例女性青少年(n=80；男性年龄=14.6±0.9；男性BMI=21.9±3.6；41%有父母饮食病史)在接受食物过程中的神经反应。结果：与正常体重的女性相比，超重/肥胖女性的腹内侧额前皮质(VmPFC)和腹侧前扣带回(ACC)对奶昔提示的反应更大，腹侧纹状体、膝下额叶皮质和背内侧前额叶皮质对奶昔的反应更大。有超重/肥胖和父母饮食病史的女性比那些没有父母饮食病史和体重正常的女性对奶昔提示的vmPFC/内侧眶前皮质的反应更大。超重/肥胖和没有父母饮食病史的女性对收到奶昔的丘脑和纹状体有更大的反应。结论：超重/肥胖与奖励区域对美味食物提示和食物接收的反应升高有关。对于超重的人来说，进食病理的风险会增强奖励区域对食物提示的反应。
Objective: To test whether overweight/obesity is associated with an elevated reward region response to milkshake cues and a low reward region response to milkshake receipt. To test whether the risk for eating pathology moderates the effects of weight status on the neural response to milkshake cues and milkshake receipt. Method: The current study used functional magnetic resonance imaging (fMRI) to examine the neuronal responses of female adolescents (n = 80; M age = 14.6 ± 0.9; M BMI = 21.9 ± 3.6; 41% with a biological parental history of eating pathology) during a food receipt paradigm. Results: Females with overweight/obesity showed a greater ventromedial prefrontal cortex (vmPFC), and ventral anterior cingulate (ACC) response to milkshake cues and a greater ventral striatum, subgenual ACC, and dorsomedial prefrontal cortex response to milkshake receipt than those with a healthy weight. Females with overweight/obesity plus a parental history of eating pathology showed a greater vmPFC/medial orbitofrontal cortex response to milkshake cues than those without a parental history of eating pathology and those with a healthy weight. Females with overweight/obesity and without a parental history of eating pathology showed a greater thalamus and striatum response to milkshake receipt. Conclusions: Overweight/obesity is associated with an elevated reward region response to palatable food cues and food receipt. A risk for eating pathology enhances the reward region response to food cues in those with excess weight.
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影响因子：
56.9
作者：
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