Anti-Interleukin-1 Agents in Adult Onset Still's Disease.
Anti-Interleukin-1 Agents in Adult Onset Still's Disease.
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DOI：
10.1155/2012/317820
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发表时间：
2012
影响因子：
2
通讯作者：
Fautrel B
中科院分区：
文献类型：
--
作者：
Giampietro C;Fautrel B
白细胞介素1β（IL-1β）是成人斯蒂尔病（AOSD）发病机制的主要介质。这种多效性细胞因子的表达受炎性体途径的控制，具有广泛的作用类型。作为先天免疫的关键介质，它是一种强效热原，并促进嗜酸性细胞增殖和渗出到炎症组织中，这是AOSD的关键表现。对AOSD患者血清和病理组织中促炎细胞因子谱的研究表明，IL-1β水平升高，这些水平与疾病活动性和严重程度高度相关。这些实验证据以及与具有AOSD临床和生物学特征的其他自身炎性疾病的相似性表明，阻断IL-1β是AOSD的一种可能的新治疗选择，特别是在常规治疗抵抗的病例中。阿那白滞素是第一个投入市场的抗IL-1药物，已证明能够诱导快速反应，特别是在抗TNF α未能控制症状的全身形式中。虽然越来越多的证据支持阿那白滞素在AOSD中的应用，但新一代抗IL 1 β拮抗剂正在开发中。Canakinumab和rilonacept由于其更高的亲和力和更长的半衰期，可以改善这种无效疾病的管理。
Interleukin 1β (IL-1β) is emerging as a master mediator of adult onset Still's disease (AOSD) pathogenesis. This pleiotropic cytokine, whose expression is under the control of the inflammasome pathway, has a wide type of effects. As a key mediator of innate immunity is a potent pyrogen and facilitates neutrophilic proliferation and diapedesis into the inflamed tissues, which are key AOSD manifestations. The study of proinflammatory cytokines profiles in sera and pathological tissues of AOSD patients has shown elevated levels of IL-1β, these levels being highly correlated with disease activity and severity. These experimental evidences and the analogy with other autoinflammatory diseases that share with AOSD clinical and biological characteristics have suggested the blockade of IL-1β as a possible new therapeutic option for the AOSD, especially in conventional therapy resistant cases. Anakinra, the first anti-IL-1 agent put on the market, has demonstrated capable to induce a rapid response sustained over time, especially in systemic forms, where anti-TNFα failed to control symptoms. While a growing number of evidences supports the utilisation of anakinra in AOSD, a new generation of anti-IL1β antagonists is developing. Canakinumab and rilonacept, thanks to their higher affinity and longer half-life, could improve the management of this invalidating disease.
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影响因子：
27.4
作者：
Godinho, FMV;Santos, MJP;da Silva, JC
通讯作者：
da Silva, JC
影响因子：
5.2
作者：
Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R
DOI：
10.1016/j.berh.2008.08.006
发表时间：
2008-10-01
影响因子：
5.2
作者：
Fautrel, Bruno
通讯作者：
Fautrel, Bruno
影响因子：
5.5
作者：
Chen, Der-Yuan;Chen, Yi-Ming;Hsieh, Chia-Wei
通讯作者：
Hsieh, Chia-Wei
影响因子：
27.4
作者：
Gul, Ahmet;Tugal-Tutkun, Ilknur;Solinger, Alan
通讯作者：
Solinger, Alan