A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination.
A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination.
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DOI：
10.3390/vaccines9080856
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发表时间：
2021-08-04
期刊：
影响因子：
7.8
通讯作者：
Ikeda SI
中科院分区：
文献类型：
--
作者：
Hineno A;Ikeda SI
在日本，相当数量的青春期女性在接种人类乳头瘤病毒（HPV）疫苗后出现了不寻常的症状，其中绝大多数人最初被诊断为精神疾病，因为没有病理放射图像和实验室检查结果中的特定异常。后来这些症状被认为是HPV疫苗接种的不良反应。然而，HPV疫苗接种与这些症状之间的因果关系尚未得到证实。在2013年6月至2021年3月期间，我们检查了200名在接种HPV疫苗后出现各种症状的患者。根据我们提出的诊断标准，总共有87例被诊断为HPV疫苗相关症状。分析87例患者的临床病史。首次接种疫苗的年龄范围为11 ~ 19岁（平均±SD: 13.5±1.5岁），首次出现症状的年龄范围为12 ~ 20岁（平均±SD: 14.3±1.6岁）。患者在2010年5月至2013年5月期间接受了首次HPV疫苗注射，但第一例患者于2010年10月出现症状，最后一例患者于2015年10月出现症状。在过去五年中，日本没有出现hpv疫苗接种后疾病的聚集性患者。我们的研究表明，在日本，HPV疫苗接种时期与HPV疫苗接种后独特的疾病发展时期相当重叠。这种疾病表现为站立不耐受、慢性局部疼痛综合征和认知功能障碍的组合，但其确切的发病机制尚不清楚。
In Japan, a significant number of adolescent females noted unusual symptoms after receiving the human papillomavirus (HPV) vaccination, of which the vast majority of them were initially diagnosed with psychiatric illnesses because of the absence of pathologic radiological images and specific abnormalities in laboratory test results. Later these symptoms were thought to be adverse effects of HPV vaccination. However, a causal link between HPV vaccination and the development of these symptoms has not been demonstrated. Between June 2013 and March 2021, we examined 200 patients who noted various symptoms after HPV vaccination. In total, 87 were diagnosed with HPV vaccination-related symptoms based on our proposed diagnostic criteria. The clinical histories of these 87 patients were analyzed. The age at initial vaccination ranged from 11 to 19 years old (mean ± SD: 13.5 ± 1.5 years old), and the age at the first appearance of symptoms ranged from 12 to 20 years old (mean ± SD: 14.3 ± 1.6 years old). The patients received an initial HPV vaccine injection between May 2010 and May 2013, but the first affected patient developed symptoms in October 2010, and the last affected developed symptoms in October 2015. A cluster of patients with a post-HPV vaccination disorder has not appeared in Japan during the last five years. Our study shows that, in Japan, the period of HPV vaccination considerably overlapped with that of a unique post-HPV vaccination disorder development. This disorder appears as a combination of orthostatic intolerance, chronic regional pain syndrome, and cognitive dysfunction, but its exact pathogenesis remains unclear.
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