Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.
Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.
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DOI：
10.1016/j.nano.2011.08.019
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发表时间：
2012-02
影响因子：
5.4
通讯作者：
Zhao, Yuliang
中科院分区：
文献类型：
--
作者：
Meng, Huan;Xing, Gengmei;Blanco, Elvin;Song, Yan;Zhao, Lina;Sun, Baoyun;Li, Xiaoda;Wang, Paul C.;Korotcov, Alexandru;Li, Wei;Liang, Xing-Jie;Chen, Chunying;Yuan, Hui;Zhao, Feng;Chen, Zhen;Sun, Tong;Chai, Zhifang;Ferrari, Mauro;Zhao, Yuliang
关键词：
这项工作的目的是研究钆金属富勒烯醇纳米颗粒（f-NPs）在恶性和侵袭性人类乳腺癌模型中的抗转移活性。我们证明，f-NPs 抑制基质金属蛋白酶 (MMP) 的产生，并进一步干扰组织培养条件下癌细胞的侵袭性。在组织侵袭动物模型中，用 f-NPs 治疗的侵袭性原发肿瘤显示出异位部位的转移显着减少，同时 MMP 表达降低。在同一动物模型中，我们观察到纤维笼的形成，该纤维笼可以作为能够封装癌组织的物理屏障，切断癌症和肿瘤相关巨噬细胞之间的通讯，而巨噬细胞会产生 MMP 酶。在另一种动物模型（血液转移模型）中，f-NPs 有效抑制了肺部肿瘤灶的形成。基于这些数据，我们得出结论，f-NPs具有抗转移作用，并推测f-NPs的利用可能为治疗肿瘤转移提供新策略。
The purpose of this work is to study the antimetastasis activity of gadolinium metallofullerenol nanoparticles (f-NPs) in malignant and invasive human breast cancer models. We demonstrated that f-NPs inhibited the production of matrix metalloproteinase (MMP) enzymes and further interfered with the invasiveness of cancer cells in tissue culture condition. In the tissue invasion animal model, the invasive primary tumor treated with f-NPs showed significantly less metastasis to the ectopic site along with the decreased MMP expression. In the same animal model, we observed the formation of a fibrous cage that may serve as a physical barrier capable of cancer tissue encapsulation that cuts the communication between cancer- and tumor-associated macrophages, which produce MMP enzymes. In another animal model, the blood transfer model, f-NPs potently suppressed the establishment of tumor foci in lung. Based on these data, we conclude that f-NPs have antimetastasis effects and speculate that utilization of f-NPs may provide a new strategy for the treatment of tumor metastasis.
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影响因子：
4.8
作者：
Ran, S;Mohamedali, KA;Rosenblum, MG
通讯作者：
Rosenblum, MG
DOI：
10.1073/pnas.0707654105
发表时间：
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