Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.
Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.
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HIV-1感染新生儿的早期抗逆转录病毒治疗限制病毒库大小并诱导独特的先天免疫谱。
DOI：
10.1126/scitranslmed.aax7350
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发表时间：
2019-11-27
影响因子：
17.1
通讯作者：
Lichterfeld M
中科院分区：
文献类型：
--
作者：
Garcia-Broncano P;Maddali S;Einkauf KB;Jiang C;Gao C;Chevalier J;Chowdhury FZ;Maswabi K;Ajibola G;Moyo S;Mohammed T;Ncube T;Makhema J;Jean-Philippe P;Yu XG;Powis KM;Lockman S;Kuritzkes DR;Shapiro R;Lichterfeld M
Neonatal HIV-1 infection is associated with rapidly progressive and frequently fatal immune deficiency if left untreated. Immediate institution of antiretroviral therapy (ART), ideally within hours after birth, may restrict irreversible damage to the developing neonatal immune system and possibly provide opportunities for facilitating drug-free viral control during subsequent treatment interruptions. However, the virological and immunological effects of ART initiation within hours after delivery have not been systematically investigated. We examined a unique cohort of neonates with HIV-1 infection from Botswana who started ART shortly after birth and were followed longitudinally for about 2 years in comparison to control infants started on treatment during the first year after birth. We demonstrate multiple clear benefits of rapid antiretroviral initiation, including an extremely small reservoir of intact proviral sequences, a reduction in abnormal T cell immune activation, a more polyfunctional HIV-1–specific T cell response, and an innate immune profile that displays distinct features of improved antiviral activity and is associated with intact proviral reservoir size. Together, these data offer rare insight into the evolutionary dynamics of viral reservoir establishment in neonates and provide strong empirical evidence supporting the immediate initiation of ART for neonates with HIV-1 infection.
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影响因子：
16.6
作者：
Cesana D;Santoni de Sio FR;Rudilosso L;Gallina P;Calabria A;Beretta S;Merelli I;Bruzzesi E;Passerini L;Nozza S;Vicenzi E;Poli G;Gregori S;Tambussi G;Montini E
通讯作者：
Montini E
影响因子：
15.9
作者：
Lee, Guinevere Q.;Orlova-Fink, Nina;Lichterfeld, Mathias
通讯作者：
Lichterfeld, Mathias
影响因子：
4.4
作者：
Hebel, Katrin;Weinert, Soenke;Brunner-Weinzierl, Monika C.
通讯作者：
Brunner-Weinzierl, Monika C.
影响因子：
64.5
作者：
Ho YC;Shan L;Hosmane NN;Wang J;Laskey SB;Rosenbloom DI;Lai J;Blankson JN;Siliciano JD;Siliciano RF
通讯作者：
Siliciano RF
影响因子：
4.4
作者：
Basha S;Surendran N;Pichichero M
通讯作者：
Pichichero M