Rapid acquisition strategy for functional T1ρ mapping of the brain.
Rapid acquisition strategy for functional T1ρ mapping of the brain.
复制标题
大脑功能 T1ρ 映射的快速采集策略。
DOI：
10.1016/j.mri.2014.07.010
复制
发表时间：
2014-11
影响因子：
2.5
通讯作者：
Magnotta, Vincent A.
中科院分区：
文献类型：
--
作者：
Johnson, Casey P.;Heo, Hye-Young;Thedens, Daniel R.;Wemmie, John A.;Magnotta, Vincent A.
功能T1ρ映射已被提出作为一种具有高空间和时间分辨率的评估大脑pH和代谢动力学的方法。这项工作的目的是描述和评估一种自旋锁定回波平面成像（SLEPI）序列的变体，用于3T下的功能T1ρ映射。所提出的序列以4.0秒的时间分辨率和10片的体积覆盖快速获取T1ρ图的时间序列。模拟，幻影和体内实验用于评估序列及其实现的许多方面，包括测量T1ρ动力学的保真度，T1响应的潜在混淆，成像参数权衡，时间序列分析方法以及与BOLD fMRI相比的差异。结果表明，该序列的高时间分辨率和体积曲线是以一定的代价获得的，包括T1ρ响应的低估，对T1动态的敏感性和降低的信噪比。体内研究使用闪烁棋盘状功能磁共振成像范式提示T1ρ和BOLD激活模式之间的差异，讨论了功能T1ρ响应的可能来源和潜在的序列改进。T1ρ以高时间和空间分辨率绘制全脑pH和代谢动力学的能力具有潜在的独特性，值得进一步研究和开发。
Functional T1ρ mapping has been proposed as a method to assess pH and metabolism dynamics in the brain with high spatial and temporal resolution. The purpose of this work is describe and evaluate a variant of the spin-locked echo-planar imaging (SLEPI) sequence for functional T1ρ mapping at 3T. The proposed sequence rapidly acquires a time series of T1ρ maps with 4.0 sec temporal resolution and 10 slices of volumetric coverage. Simulation, phantom, and in vivo experiments are used to evaluate many aspects of the sequence and its implementation including fidelity of measured T1ρ dynamics, potential confounds to the T1 response, imaging parameter tradeoffs, time series analysis approaches, and differences compared to BOLD fMRI. It is shown that the high temporal resolution and volumetric cove of the sequence are obtained with some expense including underestimation of the T1ρ response, sensitivity to T1 dynamics, and reduced signal-to-noise ratio. In vivo studies using a flashing checkerboard fMRI paradigm suggest differences between T1ρ and BOLD activation pattern Possible sources of the functional T1ρ response and potential sequence improvements are discussed. The capability of T1ρ to map whole-brain pH and metabolism dynamics with high temporal and spatial resolution is potentially unique and warrants further investigation and development.
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影响因子：
5.7
作者：
Poser, B. A.;Koopmans, P. J.;Witzel, T.;Wald, L. L.;Barth, M.
通讯作者：
Barth, M.
影响因子：
10.6
作者：
Magnotta VA;Johnson CP;Follmer R;Wemmie JA
通讯作者：
Wemmie JA
影响因子：
6
作者：
Haris M;Singh A;Cai K;Davatzikos C;Trojanowski JQ;Melhem ER;Clark CM;Borthakur A
通讯作者：
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影响因子：
4.4
作者：
Borthakur, A;Wheaton, AJ;Reddy, R
通讯作者：
Reddy, R
影响因子：
3.3
作者：
Lu, Hanzhang;Donahue, Manus J.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.