Functional t1ρ imaging in panic disorder.
Functional t1ρ imaging in panic disorder.
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DOI：
10.1016/j.biopsych.2013.09.008
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发表时间：
2014-06-01
影响因子：
10.6
通讯作者：
Wemmie JA
中科院分区：
文献类型：
--
作者：
Magnotta VA;Johnson CP;Follmer R;Wemmie JA
大脑pH值异常被认为在恐慌症中起着关键作用。为了研究这种可能性，我们采用了pH敏感的磁共振（MR）成像策略（旋转坐标系中的T1弛豫[T1ρ]）和传统的血氧水平依赖性（BOLD）成像。13名惊恐障碍参与者和13名匹配的对照受试者参加了这项研究。T1ρ和BOLD用于研究视觉闪烁棋盘的功能反应及其与使用Beck焦虑量表评估的恐慌症状的关系。在对视觉刺激的反应中，T1ρ成像显示惊恐障碍参与者的视觉皮层显著增加。T1ρ还检测到前扣带皮层中的刺激诱发的减少。血氧水平依赖性成像未检测到组间的功能差异。惊恐症状和功能性T1ρ反应之间的对应关系在左顶叶下叶、左颞中回和右颞叶内发现了显著的关系。恐慌症状和BOLD信号之间没有关系。这些数据表明，惊恐障碍参与者的视觉皮层和前扣带皮层的活动诱发的T1ρ变化更大。这些观察结果与惊恐障碍中的pH失调一致。此外，我们的数据表明，T1ρ成像可以提供有关惊恐障碍的信息，这与传统的BOLD成像不同，可以反映pH值和/或脑代谢的异常。
Abnormal brain pH has been suggested to play a critical role in panic disorder. To investigate this possibility, we employed a pH-sensitive magnetic resonance (MR) imaging strategy (T1 relaxation in the rotating frame [T1ρ]) and conventional blood oxygen level-dependent (BOLD) imaging. Thirteen panic disorder participants and 13 matched control subjects were enrolled in the study. T1ρ and BOLD were used to study the functional response to a visual flashing checkerboard and their relationship to panic symptoms assessed using the Beck Anxiety Inventory. In response to visual stimulation, T1ρ imaging revealed a significantly greater increase in the visual cortex of panic disorder participants. T1ρ also detected a stimulus-evoked decrease in the anterior cingulate cortex. Blood oxygen level-dependent imaging detected no functional differences between groups. The correspondence between panic symptoms and functional T1ρ response identified significant relationships within the left inferior parietal lobe, left middle temporal gyrus, and right insula. No relationships were found between panic symptoms and the BOLD signal. The data suggest greater activity-evoked T1ρ changes in the visual cortex and anterior cingulate cortex of panic disorder participants. These observations are consistent with a pH dysregulation in panic disorder. In addition, our data suggest that T1ρ imaging may provide information about panic disorder that is distinct from conventional BOLD imaging and may reflect abnormalities in pH and/or brain metabolism.
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DOI：
10.1523/jneurosci.3907-08.2008
发表时间：
2008-12-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Coryell MW;Wunsch AM;Haenfler JM;Allen JE;McBride JL;Davidson BL;Wemmie JA
通讯作者：
Wemmie JA
影响因子：
2.3
作者：
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通讯作者：
Obrocki, Jost
影响因子：
4.1
作者：
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通讯作者：
Graeff, Frederico G.
影响因子：
17.7
作者：
Ball, S;Shekhar, A
通讯作者：
Shekhar, A
DOI：
10.1016/j.pnpbp.2006.08.004
发表时间：
2007-01-30
影响因子：
5.6
作者：
Alkin, Tunc;Tural, Umit;Kutluk, Kursad
通讯作者：
Kutluk, Kursad