DNA replication components as regulators of epigenetic inheritance--lesson from fission yeast centromere.
DNA replication components as regulators of epigenetic inheritance--lesson from fission yeast centromere.
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DOI：
10.1007/s13238-014-0049-9
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发表时间：
2014-06
期刊：
影响因子：
21.1
通讯作者：
Li, Fei
中科院分区：
文献类型：
--
作者：
He, Haijin;Gonzalez, Marlyn;Zhang, Fan;Li, Fei
储存在DNA中的遗传信息通过DNA复制被准确地复制并传递给后代。这一过程是通过高度保守的DNA复制组分的协同作用来完成的。以组蛋白修饰和DNA甲基化形式储存的表观遗传信息构成了对许多细胞过程重要的第二层调控信息，例如基因表达调控、染色质组织和基因组稳定性。在DNA复制过程中，表观遗传信息也必须忠实地传递给后代。如何完成这项艰巨的任务仍然知之甚少。在这篇综述中，我们将讨论DNA复制组件在表观遗传标记遗传中的作用的最新进展，特别关注裂殖酵母中的表观遗传调控。基于这些发现，我们提出，特定的DNA复制组件的功能作为关键的监管机构在整个基因组的表观遗传信息的复制。
Genetic information stored in DNA is accurately copied and transferred to subsequent generations through DNA replication. This process is accomplished through the concerted actions of highly conserved DNA replication components. Epigenetic information stored in the form of histone modifications and DNA methylation, constitutes a second layer of regulatory information important for many cellular processes, such as gene expression regulation, chromatin organization, and genome stability. During DNA replication, epigenetic information must also be faithfully transmitted to subsequent generations. How this monumental task is achieved remains poorly understood. In this review, we will discuss recent advances on the role of DNA replication components in the inheritance of epigenetic marks, with a particular focus on epigenetic regulation in fission yeast. Based on these findings, we propose that specific DNA replication components function as key regulators in the replication of epigenetic information across the genome.
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影响因子：
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