Heavy Ion Minibeam Therapy: Side Effects in Normal Brain.
Heavy Ion Minibeam Therapy: Side Effects in Normal Brain.
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DOI：
10.3390/cancers13246207
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发表时间：
2021-12-09
期刊：
影响因子：
5.2
通讯作者：
Waddell J
中科院分区：
文献类型：
--
作者：
Eley JG;Haga CW;Keller A;Lazenby EM;Raver C;Rusek A;Dilmanian FA;Krishnan S;Waddell J
与常规放射治疗相比，微束治疗保留了某些正常组织。最近，应用质子的微束在胶质母细胞瘤的啮齿动物模型中显示出疗效。考虑到对人类治疗的转化，较重的离子如氦-4、锂-7、碳-12或氧-16将使该方法能够更深入地进入人类大脑，潜在地保留更大体积的正常大脑;然而，该方法的生物学不确定性和潜在毒性知之甚少，特别是对于重离子。本研究探讨了重离子微束局部脑照射后，正常啮齿动物大脑中出现的认知障碍和病理变化。本工作的目的是调查是否微束治疗与重离子治疗可能会提供治疗人类脑癌的治疗比的改善。为了评估神经毒性，我们用120 MeV的锂-7离子以20戈伊的吸收积分剂量照射正常幼年大鼠。光束被配置为实心平行圆形光束或在圆形阵列内具有300微米宽度和1 mm中心到中心间距的平面平行微型光束阵列。我们在治疗后对动物进行了6个月的随访，并利用行为测试和免疫组织化学研究来研究所产生的认知障碍和慢性病理变化。我们发现，与假手术对照组相比，固体束治疗和迷你束治疗均导致认知障碍，在本研究的条件下，使用重离子迷你束代替固体束，神经毒性没有明显降低。
Minibeam therapy spares certain normal tissues compared to conventional radiation therapy. Recently, minibeams applied with protons have shown efficacy in rodent models of glioblastoma. In consideration of translation to human therapy, heavier ions such as helium-4, lithium-7, carbon-12, or oxygen-16 would enable the method to reach deeper into the human brain, potentially sparing greater volumes of normal brain; however, biologic uncertainties and potential toxicities of the method are poorly understood, especially for heavy ions. This work explores the cognitive impairments and pathologic changes seen in normal rodent brain at late timepoints after partial-brain minibeam irradiation with heavy ions. The purpose of this work was to investigate whether minibeam therapy with heavy ions might offer improvements of the therapeutic ratio for the treatment of human brain cancers. To assess neurotoxicity, we irradiated normal juvenile rats using 120 MeV lithium-7 ions at an absorbed integral dose of 20 Gy. Beams were configured either as a solid parallel circular beam or as an array of planar parallel minibeams having 300-micron width and 1-mm center-to-center spacing within a circular array. We followed animals for 6 months after treatment and utilized behavioral testing and immunohistochemical studies to investigate the resulting cognitive impairment and chronic pathologic changes. We found both solid-beam therapy and minibeam therapy to result in cognitive impairment compared with sham controls, with no apparent reduction in neurotoxicity using heavy ion minibeams instead of solid beams under the conditions of this study.
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影响因子：
9.8
作者：
McQuin C;Goodman A;Chernyshev V;Kamentsky L;Cimini BA;Karhohs KW;Doan M;Ding L;Rafelski SM;Thirstrup D;Wiegraebe W;Singh S;Becker T;Caicedo JC;Carpenter AE
通讯作者：
Carpenter AE
影响因子：
3.4
作者：
Chase, E. Alexander;Tait, David S.;Brown, Verity J.
通讯作者：
Brown, Verity J.
影响因子：
3.5
作者：
Meyer, Juergen;Stewart, Robert D.;Sandison, George
通讯作者：
Sandison, George
DOI：
10.1523/jneurosci.2820-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bissonette GB;Martins GJ;Franz TM;Harper ES;Schoenbaum G;Powell EM
通讯作者：
Powell EM
影响因子：
2.5
作者：
Lenroot, Rhoshel K.;Giedd, Jay N.
通讯作者：
Giedd, Jay N.