Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.
Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.
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DOI：
10.1016/j.biomaterials.2012.11.061
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发表时间：
2013-03
期刊：
影响因子：
14
通讯作者：
Mattson, Mark P.
中科院分区：
文献类型：
--
作者：
Chigurupati, Srinivasulu;Mughal, Mohamed R.;Okun, Eitan;Das, Soumen;Kumar, Amit;McCaffery, Michael;Seal, Sudipta;Mattson, Mark P.
关键词：
Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles.
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影响因子：
14
作者：
Das S;Singh S;Dowding JM;Oommen S;Kumar A;Sayle TX;Saraf S;Patra CR;Vlahakis NE;Sayle DC;Self WT;Seal S
通讯作者：
Seal S
影响因子：
6.1
作者：
Kong, Li;Cai, Xue;Zhou, Xiaohong;Wong, Lily L.;Karakoti, Ajay S.;Seal, Sudipta;McGinnis, James F.
通讯作者：
McGinnis, James F.
影响因子：
4.9
作者：
Dowding, Janet M.;Dosani, Talib;Self, William T.
通讯作者：
Self, William T.
影响因子：
2.9
作者：
Sidhu, Gurmel S.;Singh, Anoop K.;Maheshwari, Radha K.
通讯作者：
Maheshwari, Radha K.
影响因子：
14
作者：
Heckert, Eric G.;Karakoti, Ajay S.;Self, William T.
通讯作者：
Self, William T.