Histogram Analysis of Diffusion Kurtosis Magnetic Resonance Imaging for Diagnosis of Hepatic Fibrosis.
Histogram Analysis of Diffusion Kurtosis Magnetic Resonance Imaging for Diagnosis of Hepatic Fibrosis.
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弥散峰度磁共振成像诊断肝纤维化的直方图分析
DOI：
10.3348/kjr.2018.19.5.916
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发表时间：
2018-09
影响因子：
4.8
通讯作者：
Zeng MS
中科院分区：
文献类型：
--
作者：
Sheng RF;Jin KP;Yang L;Wang HQ;Liu H;Ji Y;Fu CX;Zeng MS
目的探讨弥散峰度成像（DKI）直方图分析在肝纤维化分期中的诊断价值。材料与方法36只大鼠随机分为四氯化碳（CCl 4）致肝纤维化模型组和对照组，每组6只，分别治疗2、4、6、8周。使用3 T扫描仪进行MRI。获得校正的表观扩散（D）、峰度（K）和表观扩散系数（ADC）的DKI直方图。根据纤维化分期和炎症活动性，生成平均值、中位数、偏度、峰度以及第25和第75位的评分，并进行比较。结果共纳入35只大鼠，其中F0 ~ F4分别为12、5、5、6、7只。平均值、中位数、第25和第75百分位数、D图峰度、中位数、第25百分位数、K图偏度和ADC图第75百分位数与纤维化分期显著相关（r =-0.767至0.339，p < 0.001至p = 0.039）。纤维化评分是与直方图参数相关的自变量，与炎症活动性分级相比（p < 0.001至p = 0.041），K图中位数除外（p = 0.185）。在纤维化分期中，D的受试者工作特征曲线下面积大于K和ADC图，但两两比较无显著差异（p = 0.0512至p = 0.847）。结论DKI直方图校正表观弥散度分析法对肝纤维化的分期具有更高的诊断价值。
Objective To investigate the diagnostic value of diffusion kurtosis imaging (DKI) histogram analysis in hepatic fibrosis staging. Materials and Methods Thirty-six rats were divided into carbon tetrachloride-induced fibrosis groups (6 rats per group for 2, 4, 6, and 8 weeks) and a control group (n = 12). MRI was performed using a 3T scanner. Histograms of DKI were obtained for corrected apparent diffusion (D), kurtosis (K) and apparent diffusion coefficient (ADC). Mean, median, skewness, kurtosis and 25th and 75th percentiles were generated and compared according to the fibrosis stage and inflammatory activity. Results A total of 35 rats were included, and 12, 5, 5, 6, and 7 rats were diagnosed as F0–F4. The mean, median, 25th and 75th percentiles, kurtosis of D map, median, 25th percentile, skewness of K map, and 75th percentile of ADC map demonstrated significant correlation with fibrosis stage (r = −0.767 to 0.339, p < 0.001 to p = 0.039). The fibrosis score was the independent variable associated with histogram parameters compared with inflammatory activity grade (p < 0.001 to p = 0.041), except the median of K map (p = 0.185). Areas under the receiver operating characteristic curve of D were larger than K and ADC maps in fibrosis staging, although no significant differences existed in pairwise comparisons (p = 0.0512 to p = 0.847). Conclusion Corrected apparent diffusion of DKI histogram analysis provides added value and better diagnostic performance to detect various liver fibrosis stages compared with ADC.
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影响因子：
1.6
作者：
Huang YQ;Liang HY;Yang ZX;Ding Y;Zeng MS;Rao SX
通讯作者：
Rao SX
影响因子：
4.8
作者：
Ahn SJ;Lee JM;Chang W;Lee SM;Kang HJ;Yang H;Yoon JH;Park SJ;Han JK
通讯作者：
Han JK
影响因子：
3.7
作者：
Kim H;Park SH;Kim EK;Kim MJ;Park YN;Park HJ;Choi JY
通讯作者：
Choi JY
影响因子：
5.9
作者：
Lambregts DM;Beets GL;Maas M;Curvo-Semedo L;Kessels AG;Thywissen T;Beets-Tan RG
通讯作者：
Beets-Tan RG
影响因子：
13.5
作者：
Bedossa, P;Poynard, T
通讯作者：
Poynard, T