Intraventricular Extension of Supratentorial Intracerebral Hemorrhage: The Modified Graeb Scale Improves Outcome Prediction in Lund Stroke Register.
Intraventricular Extension of Supratentorial Intracerebral Hemorrhage: The Modified Graeb Scale Improves Outcome Prediction in Lund Stroke Register.
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DOI：
10.1159/000442575
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发表时间：
2016
影响因子：
5.7
通讯作者：
Lindgren A
中科院分区：
文献类型：
--
作者：
Hansen BM;Morgan TC;Betz JF;Sundgren PC;Norrving B;Hanley DF;Lindgren A
改良Graeb量表（mGS）是一种半定量评估脑出血（ICH）患者脑室内出血（IVH）范围的方法。在来自便利样本的队列中，mGS已被证明可预测ICH后的结局。我们评估了mGS在幕上ICH患者中的外部效度。ICH患者前瞻性连续纳入隆德卒中登记系统。随访生存状态从国家人口普查办公室获得;功能结局从瑞典卒中登记或医疗记录获得。使用多变量分析，我们检查了mGS是否与30天生存率或90天时的不良功能结局（改良兰金量表≥ 4）相关。在198例幕上ICH患者中，86例（43%）有IVH（中位数mGS 12，范围1-28）。在多变量回归分析中，mGS独立预测ICH后30天死亡率（每点; OR 1.16; 95% CI 1.06-1.27; p = 0.002）和不良功能结局（OR 1.11; 95% CI 1.02-1.20; p = 0.011）。在接受者-操作者特征分析中，添加mGS往往与生存期的较高预后准确性相关（曲线下面积0.886 vs.不包括mGS 0.812; p = 0.053）。在脑出血人群中，mGS改善了幕上脑出血后的预后预测，超过了先前确定的其他因素。
The modified Graeb Scale (mGS) is a semi-quantitative method to assess the extension of intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH). The mGS has been shown to prognosticate outcome after ICH in cohorts derived from convenience samples. We evaluated the external validity of mGS in supratentorial ICH-patients from an unselected cohort. ICH-patients were included prospectively and consecutively in Lund Stroke Register. Follow-up survival status was obtained from the National Census Office; functional outcome was obtained from the Swedish Stroke Register or medical records. Using multivariate analyses, we examined if mGS was related to 30-day survival or poor functional outcome (modified Rankin Scale ≥ 4) at 90 days. Of 198 supratentorial ICH-patients, 86 (43%) had IVH (median mGS 12, range 1–28). In multivariate regression analyses, the mGS independently predicted 30-day mortality (per point; OR 1.16; 95% CI 1.06–1.27; p = 0.002) and poor functional outcome (OR 1.11; 95% CI 1.02–1.20; p = 0.011) after ICH. In receiver-operator characteristic analysis, the addition of mGS tended to be associated with a higher prognostic accuracy for survival (area under curve 0.886 vs. not including mGS 0.812; p = 0.053). The mGS improves outcome prediction after supratentorial ICH beyond other previously established factors in an unselected population.
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影响因子：
8.3
作者：
Morgan TC;Dawson J;Spengler D;Lees KR;Aldrich C;Mishra NK;Lane K;Quinn TJ;Diener-West M;Weir CJ;Higgins P;Rafferty M;Kinsley K;Ziai W;Awad I;Walters MR;Hanley D;CLEAR and VISTA Investigators
通讯作者：
CLEAR and VISTA Investigators
影响因子：
8.3
作者：
Hemphill, JC;Bonovich, DC;Johnston, SC
通讯作者：
Johnston, SC
影响因子：
9.9
作者：
Lee, S. -H.;Kim, B. J.;Yoon, B. -W.
通讯作者：
Yoon, B. -W.
影响因子：
37.8
作者：
Cook, Nancy R.
通讯作者：
Cook, Nancy R.
影响因子：
3.5
作者：
Hallstrom, B.;Jonsson, A. -C.;Lindgren, A.
通讯作者：
Lindgren, A.