Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces.
Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces.
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DOI：
10.1007/s00415-022-10971-w
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发表时间：
2022-06
影响因子：
6
通讯作者：
Lunetta C
中科院分区：
文献类型：
--
作者：
Pugliese R;Sala R;Regondi S;Beltrami B;Lunetta C
肌萎缩侧索硬化症（ALS），也称为运动神经元疾病，其特征在于上和下运动神经元的变性，这导致肌肉无力和随后的瘫痪。它开始微妙地与局灶性无力，但无情地蔓延到涉及大多数肌肉，从而证明是有效的不治之症。通常情况下，由于呼吸麻痹导致的死亡发生在3-5年内。到目前为止，已经证明ALS患者的管理最好通过多学科方法实现，并在新兴技术的帮助下，从多学科远程会诊（用于监测吞咽困难，呼吸功能和营养状况）到脑机接口和眼动跟踪，以替代增强通信，直到机器人技术，它可以提高有效性。COVID-19大流行催生了一种在临床实践中加快开发和实施此类技术的间歇性需求，以改善ALS患者和护理人员的日常生活。然而，尽管在这一领域取得了显著进展，但仍有一些问题有待解决。本综述将讨论ALS新兴技术的尤里卡时刻，不仅作为神经退行性疾病的蓝图，还将研究目前已经到位或正在评估的技术，突出未来临床应用的利弊。
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and subsequently paralysis. It begins subtly with focal weakness but spreads relentlessly to involve most muscles, thus proving to be effectively incurable. Typically, death due to respiratory paralysis occurs in 3–5 years. To date, it has been shown that the management of ALS patients is best achieved with a multidisciplinary approach, and with the help of emerging technologies ranging from multidisciplinary teleconsults (for monitoring the dysphagia, respiratory function, and nutritional status) to brain-computer interfaces and eye tracking for alternative augmentative communication, until robotics, it may increase effectiveness. The COVID-19 pandemic created a spasmodic need to accelerate the development and implementation of such technologies in clinical practice, to improve the daily lives of both ALS patients and caregivers. However, despite the remarkable strides that have been made in the field, there are still issues to be addressed. This review will be discussed on the eureka moment of emerging technologies for ALS, used as a blueprint not only for neurodegenerative diseases, examining the current technologies already in place or being evaluated, highlighting the pros and cons for future clinical applications.
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DOI：
10.1007/s10072-020-04783-x
发表时间：
2021-01
期刊：
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
影响因子：
--
作者：
Bombaci A;Abbadessa G;Trojsi F;Leocani L;Bonavita S;Lavorgna L;Digital Technologies, Web and Social Media Study Group of the Italian Society of Neurology
通讯作者：
Digital Technologies, Web and Social Media Study Group of the Italian Society of Neurology
影响因子：
3.1
作者：
Cipresso, Pietro;Carelli, Laura;Solca, Federica;Meazzi, Daniela;Meriggi, Paolo;Poletti, Barbara;Lule, Dorothee;Ludolph, Albert C.;Silani, Vincenzo;Riva, Giuseppe
通讯作者：
Riva, Giuseppe
影响因子：
3.4
作者：
Govindarajan, Raghav;Berry, James D.;Simmons, Zachary
通讯作者：
Simmons, Zachary
影响因子：
10
作者：
Adner, R;Levinthal, DA
通讯作者：
Levinthal, DA
影响因子：
3.9
作者：
Steinbach R;Prell T;Gaur N;Stubendorff B;Roediger A;Ilse B;Witte OW;Grosskreutz J
通讯作者：
Grosskreutz J