Diurnal changes in the efficiency of information transmission at a sensory synapse.
Diurnal changes in the efficiency of information transmission at a sensory synapse.
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DOI：
10.1038/s41467-022-30202-0
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发表时间：
2022-05-12
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Neuromodulators adapt sensory circuits to changes in the external world or the animal’s internal state and synapses are key control sites for such plasticity. Less clear is how neuromodulation alters the amount of information transmitted through the circuit. We investigated this question in the context of the diurnal regulation of visual processing in the retina of zebrafish, focusing on ribbon synapses of bipolar cells. We demonstrate that contrast-sensitivity peaks in the afternoon accompanied by a four-fold increase in the average Shannon information transmitted from an active zone. This increase reflects higher synaptic gain, lower spontaneous “noise” and reduced variability of evoked responses. Simultaneously, an increase in the probability of multivesicular events with larger information content increases the efficiency of transmission (bits per vesicle) by factors of 1.5-2.7. This study demonstrates the multiplicity of mechanisms by which a neuromodulator can adjust the synaptic transfer of sensory information. Neuromodulators can adjust how sensory signals are processed. In this study, the authors demonstrate how time of day affects the way information is transmitted in the zebrafish retina.
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影响因子：
16.2
作者：
Esposti F;Johnston J;Rosa JM;Leung KM;Lagnado L
通讯作者：
Lagnado L
影响因子：
5.5
作者：
ASHMORE, JF;COPENHAGEN, DR
通讯作者：
COPENHAGEN, DR
影响因子：
5.3
作者：
Goel M;Mangel SC
通讯作者：
Mangel SC
影响因子：
16.2
作者：
Chalifoux JR;Carter AG
通讯作者：
Carter AG
影响因子：
7.8
作者：
DeWeese, MR;Meister, M
通讯作者：
Meister, M