Measurement of aortic intimal-medial thickness in adolescents and young adults.
Measurement of aortic intimal-medial thickness in adolescents and young adults.
复制标题
DOI：
10.1016/j.ultrasmedbio.2010.01.002
复制
发表时间：
2010-04
影响因子：
2.9
通讯作者：
Sonkaz, Milan
中科院分区：
文献类型：
--
作者：
Davis, Patricia H.;Dawson, Jeffrey D.;Blecha, M. Beth;Mastbergen, Rebecca K.;Sonkaz, Milan
动脉粥样硬化始于儿童时期的腹主动脉远端，后来累及颈动脉。检测这些病变的无创筛查可能允许早期干预。禁食8小时后，获得主动脉远端10mm的超声图像，并通过自动程序进行分析，以确定远壁平均内膜-内侧厚度（IMT）。将结果与同时获得的平均颈动脉IMT进行比较。313名男性和322名女性的平均年龄为20.4岁（SD 5.6）， 61名参与者进行了第二次研究以评估可重复性。男性平均主动脉IMT为0.63 mm (SD 0.14)，女性平均颈动脉IMT为0.61 mm (SD 0.13)，颈动脉IMT为0.50 mm （SD 0.04）和0.49 mm （SD 0.04）。95%的参与者进行了图像分析。平均主动脉IMT的受试者内再现性变异系数为18%，平均绝对差为0.12 mm （SD 0.10）。对于cIMT，结果分别为3%和0.02 mm （SD 0.01）。主动脉IMT可以在正常青少年和年轻人中测量，数据缺失率低，可重复性好。主动脉IMT随年龄增加的速率大于颈动脉IMT。
Atherosclerosis begins in childhood in the distal abdominal aorta and later involves the carotid arteries. Noninvasive screening to detect these lesions may allow early intervention. Ultrasound images of the distal 10 mm of the aorta were obtained after an 8-hour fast and were analyzed by an automated program to determine the mean far wall intimal-medial thickness (IMT). The results were compared to the mean carotid IMT obtained concurrently. The mean age of the 313 males and 322 females imaged was 20.4 years (SD 5.6) and 61 participants had a second study to assess reproducibility. The mean aortic IMT was 0.63 mm (SD 0.14) for males and 0.61 mm (SD 0.13) for females while the mean carotid IMT was 0.50 (SD 0.04) mm and 0.49 (SD 0.04) mm respectively. Images were analyzed in 95% of participants. Intra-subject reproducibility for the mean aortic IMT had a coefficient of variation of 18% with a mean absolute difference of 0.12 mm (SD 0.10). For cIMT, the results were 3% and 0.02 mm (SD 0.01), respectively. Aortic IMT can be measured in normal adolescents and young adults with low rates of missing data and reasonable reproducibility. Aortic IMT increased with age at a greater rate than carotid IMT.
登录
查看更多内容
影响因子：
3.6
作者：
Gunes, Tamer;Koklu, Esad;Koklu, Selmin
通讯作者：
Koklu, Selmin
影响因子：
37.8
作者：
Davis, PH;Dawson, JD;Lauer, RM
通讯作者：
Lauer, RM
影响因子：
4.9
作者：
Jourdan, C;Wühl, E;Schaefer, F
通讯作者：
Schaefer, F
影响因子：
8.3
作者：
Espeland, MA;Craven, TE;Furberg, CD
通讯作者：
Furberg, CD
影响因子：
8
作者：
Daniels, Stephen R.;Greer, Frank R.
通讯作者：
Greer, Frank R.