Synthesis, crystal structure, DNA binding, and DNA cleavage of a zinc complex containing N,N-bis(2-pyridylmethyl)amine
Synthesis, crystal structure, DNA binding, and DNA cleavage of a zinc complex containing N,N-bis(2-pyridylmethyl)amine
复制标题
含 N,N-双(2-吡啶甲基)胺的锌络合物的合成、晶体结构、DNA 结合和 DNA 切割
DOI：
10.1080/00958972.2011.600124
复制
发表时间：
2011-07
影响因子：
1.9
通讯作者：
Yan, Shi-Ping
中科院分区：
文献类型：
--
作者：
Qian, Jing;Wang, Li-Ping;Gu, Wen;Liu, Xin;Tian, Jin-Lei;Yan, Shi-Ping
制备水溶性锌络合物[Zn(bpea)Cl2] (1) (bpea = N,N-双(2-吡啶基甲基)乙胺)作为核酸酶模拟物。该复合物通过 X 射线、红外和紫外光谱进行了表征。通过紫外吸收和荧光光谱研究了该复合物与小牛胸腺 DNA (ct-DNA) 的相互作用；已提出1的ct-DNA结合模式。 DNA 裂解活性 1 是在没有外部试剂的情况下进行的。研究了不同复合物浓度或反应时间对DNA切割的影响。
A water-soluble zinc complex, [Zn(bpea)Cl2] (1) (bpea = N,N-bis(2-pyridylmethyl)ethylamine), was prepared to serve as a nuclease mimic. The complex was characterized by X-ray, infrared, and UV spectroscopy. Interactions of the complex with calf thymus-DNA (ct-DNA) have been investigated by UV absorption and fluorescence spectroscopies; the mode of ct-DNA binding for 1 has been proposed. DNA cleavage activities by 1 were performed in the absence of external agents. The influences of different complex concentrations or reaction times on DNA cleavage were studied.
登录
查看更多内容
影响因子：
4.6
作者：
Dirk Badura;H. Vahrenkamp
通讯作者：
Dirk Badura;H. Vahrenkamp
影响因子：
4
作者：
Jing Qian;W. Gu;Hui Liu;Feng-Xian Gao;Li Feng;Shi‐Ping Yan;D. Liao;P. Cheng
通讯作者：
Jing Qian;W. Gu;Hui Liu;Feng-Xian Gao;Li Feng;Shi‐Ping Yan;D. Liao;P. Cheng
影响因子：
4.6
作者：
C. Pal;Surajit Chattopadhyay;C. Sinha;A. Chakravorty
通讯作者：
C. Pal;Surajit Chattopadhyay;C. Sinha;A. Chakravorty
影响因子：
15
作者：
Fitzsimons, MP;Barton, JK
通讯作者：
Barton, JK
影响因子：
15
作者：
REICHMANN, ME;RICE, SA;DOTY, P
通讯作者：
DOTY, P