The risk of breast cancer associated with specific patterns of migraine history.
The risk of breast cancer associated with specific patterns of migraine history.
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DOI：
10.1007/s10552-014-0479-y
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发表时间：
2014-12
影响因子：
2.3
通讯作者：
Li, Christopher I.
中科院分区：
文献类型：
--
作者：
Lowry, Sarah J.;Malone, Kathleen E.;Cushing-Haugen, Kara L.;Li, Christopher I.
研究表明，偏头痛史可能与某些类型的乳腺癌风险降低有关，尽管生物学机制尚不清楚。确定与乳腺癌风险最密切相关的偏头痛的具体特征可以提高我们对这种关系的理解。我们确定了女性偏头痛病史的具体特征（严重程度、时间特征、偏头痛先兆的存在）。我们使用多分类logistic回归来估计与自我报告的偏头痛病史特征相关的ER+导管型、ER-导管型、ER+小叶型和ER+导管-小叶型乳腺癌的风险。715例乳腺癌病例（276例ER+导管癌，46例ER-导管癌，191例ER+小叶癌，202例ER+导管-小叶癌）和376例对照，年龄55-74岁。与没有偏头痛病史的女性相比，有>30年偏头痛病史的女性有60%的偏头痛。（95% CI：0.2-0.6）ER+导管型乳腺癌风险较低; 20岁之前首次发生偏头痛的患者ER+导管型和ER+小叶型乳腺癌风险降低50%（95%CI：0.3-0.9），有先兆偏头痛的女性患ER+导管和ER+小叶乳腺癌的风险分别降低30%（95%CI：0.5-0.98）和40%（95%CI：0.4-0.9）。与偏头痛相关的ER+乳腺癌风险较低似乎仅限于那些早期发作或长期偏头痛史的女性，或那些经历过先兆偏头痛的女性。这扩展了我们对偏头痛和乳腺癌之间关系的理解，并为潜在的潜在生物学机制提供了额外的见解。
Studies have suggested that a history of migraines may be associated with a lower risk of some types of breast cancer, though biological mechanisms are unclear. Identifying specific characteristics of migraines which are most strongly associated with breast cancer risk could improve our understanding of this relationship. We ascertained specific characteristics of women's migraine histories (severity, timing features, presence of migraine aura). We used polytomous logistic regression to estimate the risk of ER+ ductal, ER- ductal, ER+ lobular, and ER+ ductal-lobular breast cancer associated with self-reported characteristics of migraine history. 715 breast cancer cases (276 ER+ ductal, 46 ER- ductal, 191 ER+ lobular, 202 ER+ ductal-lobular) and 376 controls ages 55-74 years were included in this population-based case-control study. Compared to women without a migraine history, women with a >30-year history of migraines had a 60% (95% CI: 0.2-0.6) lower risk of ER+ ductal breast cancer; those who had their first migraine before age 20 had 50% lower risks of ER+ ductal and ER+ lobular breast cancer (both 95%CIs: 0.3-0.9), and women who experienced migraine with aura had 30% (95%CI 0.5-0.98) and 40% (95%CI: 0.4-0.9) lower risks of ER+ ductal and ER+ lobular breast cancer, respectively. The lower risk of ER+ breast cancer associated with migraine appears to be limited to those women with early onset or long duration of migraine history, or those who experienced migraine with aura. This expands our understanding of the relationship between migraine and breast cancer and provides additional insight into potential underlying biological mechanisms.
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影响因子：
45.3
作者：
Li, Christopher I.;Mathes, Robert W.;Prentice, Ross
通讯作者：
Prentice, Ross
影响因子：
5
作者：
Buse, Dawn C.;Loder, Elizabeth W.;Lipton, Richard B.
通讯作者：
Lipton, Richard B.
影响因子：
5
作者：
Bigal, Marcelo;Krymchantowski, Abouch Valenty;Lipton, Richard B.
通讯作者：
Lipton, Richard B.
DOI：
10.1093/jnci/djq316
发表时间：
2010-09-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Li, Christopher I.;Chlebowski, Rowan T.;Prentice, Ross
通讯作者：
Prentice, Ross
绝经后妇女的偏头痛和侵入性乳腺癌的风险。
DOI：
10.1158/1055-9965.epi-08-0527
发表时间：
2008-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Mathes RW;Malone KE;Daling JR;Davis S;Lucas SM;Porter PL;Li CI
通讯作者：
Li CI