Environmental certainty influences the neural systems regulating responses to threat and stress.
Environmental certainty influences the neural systems regulating responses to threat and stress.
复制标题
DOI：
10.1016/j.neubiorev.2021.10.014
复制
发表时间：
2021-12
影响因子：
8.2
通讯作者：
Baratta MV
中科院分区：
文献类型：
--
作者：
Meyer HC;Sangha S;Radley JJ;LaLumiere RT;Baratta MV
根据环境灵活校准威胁响应是一个自适应过程，允许动物避免伤害，同时还保持参与其他目标导向的行动。这种校准过程被称为威胁反应调节，要求动物计算给定遭遇将导致威胁的概率，以便它们能够相应地做出反应。在这里，我们回顾了两种高度研究的威胁反应抑制形式的神经相关性：灭绝和安全条件反射。我们专注于如何在周围环境中的确定性或不确定性的相对水平改变这些过程的获取和应用。我们还讨论了证据表明改变威胁反应调节压力暴露后，包括增强恐惧条件反射，破坏灭绝和安全条件反射。最后，我们讨论了研究使用动物模型的应对，探讨压力源的可控性对威胁反应的影响，突出了以前的经验与控制，或其他形式的应对，以防止未来逆境的影响的潜力。
Flexible calibration of threat responding in accordance with the environment is an adaptive process that allows an animal to avoid harm while also maintaining engagement of other goal-directed actions. This calibration process, referred to as threat response regulation, requires an animal to calculate the probability that a given encounter will result in a threat so they can respond accordingly. Here we review the neural correlates of two highly studied forms of threat response suppression: extinction and safety conditioning. We focus on how relative levels of certainty or uncertainty in the surrounding environment alter the acquisition and application of these processes. We also discuss evidence indicating altered threat response regulation following stress exposure, including enhanced fear conditioning, and disrupted extinction and safety conditioning. To conclude, we discuss research using an animal model of coping that examines the impact of stressor controllability on threat responding, highlighting the potential for previous experiences with control, or other forms of coping, to protect against the effects of future adversity.
登录
查看更多内容
影响因子：
2.7
作者：
Berlau, Daniel J.;McGaugh, James L.
通讯作者：
McGaugh, James L.
影响因子：
2.9
作者：
BARRETT, BA;CAZA, P;SPEAR, LP
通讯作者：
SPEAR, LP
影响因子：
10.6
作者：
Baratta MV;Kodandaramaiah SB;Monahan PE;Yao J;Weber MD;Lin PA;Gisabella B;Petrossian N;Amat J;Kim K;Yang A;Forest CR;Boyden ES;Goosens KA
通讯作者：
Goosens KA
影响因子：
6.8
作者：
Bloodgood DW;Sugam JA;Holmes A;Kash TL
通讯作者：
Kash TL
影响因子：
5.3
作者：
Amat, Jose;Paul, Evan;Maier, Steven F.
通讯作者：
Maier, Steven F.