Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats.
Transcutaneous vagus nerve stimulation induces tidal melatonin secretion and has an antidiabetic effect in Zucker fatty rats.
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经皮迷走神经刺激诱导潮式褪黑激素分泌并在 Zucker 肥胖大鼠中具有抗糖尿病作用
DOI：
10.1371/journal.pone.0124195
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Rong P
中科院分区：
文献类型：
--
作者：
Wang S;Zhai X;Li S;McCabe MF;Wang X;Rong P
褪黑素通过调节葡萄糖代谢在2型糖尿病（T2D）中发挥保护作用。经皮迷走神经刺激（taVNS）是否具有抗糖尿病作用，褪黑激素的调节是否参与taVNS的抗糖尿病机制尚不清楚。在本研究中，连续5周麻醉下，对Zucker糖尿病肥胖（ZDF, fa/fa）和Zucker瘦弱（ZL, +/fa）幼崽进行无创taVNS，每天1次，每次30min。研究了taVNS对褪黑激素分泌的急性和慢性影响，以及taVNS对血糖代谢的影响。我们发现naïve ZDF大鼠随着年龄的增长自然发生高血糖。每次taVNS过程都会触发褪黑激素在taVNS过程中和之后的潮汐分泌，并诱导急性两期血糖变化，急剧上升，然后逐渐下降。每日一次taVNS疗程最终在7天内将葡萄糖浓度降至正常水平，并在连续5周应用后有效维持正常的血糖和血浆糖化血红蛋白（HbAlc）水平。taVNS的这些有益作用也存在于松果体切除的大鼠中，否则会表现出明显和持续的高血糖、高胰岛素血症和高HbAlc水平。我们的结论是，多次taVNS通过触发褪黑激素的潮汐分泌来抑制t2dm。这一发现可能对开发治疗T2D的新方法具有潜在的重要性，T2D非常普遍，用任何现有方法都无法治愈，而且对世界来说成本很高。
Melatonin plays a protective role in type 2 diabetes (T2D) through regulation of glucose metabolism. Whether transcutaneous vagus nerve stimulation (taVNS) is antidiabetic and whether a modulated melatonin production is involved in the antidiabetic mechanism of taVNS is unknown. In this study, once daily 30min noninvasive taVNS was administered in Zucker diabetic fatty (ZDF, fa/fa) and Zucker lean (ZL, +/fa) littermates under anesthesia for 5 consecutive weeks. The acute and chronic influences of taVNS on the secretion of melatonin were studied as well as the effects of taVNS on blood glucose metabolism. We found that naïve ZDF rats develop hyperglycemia naturally with age. Each taVNS session would trigger a tidal secretion of melatonin both during and after the taVNS procedure and induce an acute two-phase glycemic change, a steep increase followed by a gradual decrease. Once daily taVNS sessions eventually reduced the glucose concentration to a normal level in seven days and effectively maintained the normal glycemic and plasma glycosylated hemoglobin (HbAlc) levels when applied for five consecutive weeks. These beneficial effects of taVNS also exist in pinealectomized rats, which otherwise would show overt and continuous hyperglycemia, hyperinsulinemia, and high HbAlc levels. We concluded that multiple taVNS sessions are antidiabetic in T2D through triggering of tidal secretion of melatonin. This finding may have potential importance in developing new approaches to the treatment of T2D, which is highly prevalent, incurable with any current approaches, and very costly to the world.
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DOI：
10.1038/oby.2010.24
发表时间：
2010-09
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Contreras-Alcantara S;Baba K;Tosini G
通讯作者：
Tosini G
影响因子：
8.2
作者：
Langenberg C;Pascoe L;Mari A;Tura A;Laakso M;Frayling TM;Barroso I;Loos RJ;Wareham NJ;Walker M;RISC Consortium
通讯作者：
RISC Consortium
影响因子：
5.8
作者：
Gerdin, MJ;Masana, MI;Dubocovich, ML
通讯作者：
Dubocovich, ML
影响因子：
3.2
作者：
MATTHEWS, DR;RUDENSKI, AS;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
10.3
作者：
Peschke, Elmar;Stumpf, Ina;Muehlbauer, Eckhard
通讯作者：
Muehlbauer, Eckhard