Benefits of skin biopsy of senile hemangioma in intravascular large B-cell lymphoma: A case report and review of the literature.
Benefits of skin biopsy of senile hemangioma in intravascular large B-cell lymphoma: A case report and review of the literature.
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DOI：
10.3892/ol.2014.2017
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发表时间：
2014-06
期刊：
影响因子：
2.9
通讯作者：
Ikehara S
中科院分区：
文献类型：
--
作者：
Adachi Y;Kosami K;Mizuta N;Ito M;Matsuoka Y;Kanata M;Akiyama H;Murao T;Li M;Ieki R;Ikehara S
血管内大b细胞淋巴瘤（IVLBCL）是一种罕见的b细胞淋巴瘤亚型，其特征是克隆b细胞在包括肝、脾、肺、皮肤、脑和肾在内的各种器官的小血管腔内选择性生长。86岁男性，表现为体重减轻、发热和盗汗（称为B型症状）。血液检查全血细胞减少，乳酸脱氢酶高，可溶性白介素-2受体高，提示造血系统恶性肿瘤。外周血未见造血细胞异常。全身计算机断层扫描检查未发现淋巴结肿胀。因此，怀疑IVLBCL，随机皮肤活检和老年性血管瘤皮肤活检进行。随机皮肤活检的真皮深层和皮下组织的小血管中存在少量大的非典型淋巴样细胞，在老年性血管瘤的小血管中发现大量非典型淋巴样细胞。这些结果提示老年性血管瘤皮肤活检诊断IVLBCL的有用性。
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of B-cell lymphoma characterized by selective growth of clonal B-cells in the lumen of the small vessels of various organs including the liver, spleen, lungs, skin, brain, and kidney. An 86-year-old male presented with weight loss, fever and night sweats (known as B symptoms). Blood examination revealed pancytopenia, high lactate dehydrogenase and high soluble interleukin-2 receptor, suggesting hematopoietic malignancy. However, there were no abnormal hematopoietic cells in the peripheral blood. No lymph node swelling was identified on examination by whole-body computed tomography scan. Therefore, IVLBCL was suspected, and random skin biopsies and a skin biopsy from a senile hemangioma were carried out. A small number of large atypical lymphoid cells resided in the small blood vessels in the deep dermis and subcutaneous tissue of the random skin biopsies, and numerous atypical lymphoid cells were identified in the small vessels of the senile hemangioma. These results suggest the usefulness of skin biopsy from senile hemangiomas in the diagnosis of IVLBCL.
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