Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum.
Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum.
复制标题
DOI：
10.1111/1751-7915.12055
复制
发表时间：
2014-01
影响因子：
5.7
通讯作者：
Kalinowski J
中科院分区：
文献类型：
--
作者：
Kulis-Horn RK;Persicke M;Kalinowski J
L-组氨酸生物合成是存在于细菌、古细菌、低等真核生物和植物中的古老代谢途径。几十年来，主要在大肠杆菌和鼠伤寒沙门氏菌中研究了L-组氨酸的生物合成，揭示了细菌中的基本调节过程。此外，在过去的15年中，还在工业氨基酸生产细菌谷氨酸棒杆菌中对该途径进行了深入研究，揭示了与E. coli和革兰氏阳性菌S.鼠伤寒以及差异。本文综述了近年来C.谷氨酸。描述了涉及的基因和相应的酶，特别是集中在咪唑甘油-磷酸合酶（HisFH）和组氨酸-磷酸磷酸酶（HisN）。在C.也报道了谷氨酸，包括四个组氨酸操纵子和它们的启动子。综述了严格应答和组氨酸自身转录调控的相关知识，并讨论了组氨酸转运系统的翻译调控机制。最后，我们讨论了使用这些知识来创建或改进C语言的潜力。用于工业生产L-组氨酸的谷氨酸菌株。
l-Histidine biosynthesis is an ancient metabolic pathway present in bacteria, archaea, lower eukaryotes, and plants. For decades l-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria. Furthermore, in the last 15 years this pathway has been also investigated intensively in the industrial amino acid-producing bacterium Corynebacterium glutamicum, revealing similarities to E. coli and S. typhimurium, as well as differences. This review summarizes the current knowledge of l-histidine biosynthesis in C. glutamicum. The genes involved and corresponding enzymes are described, in particular focusing on the imidazoleglycerol-phosphate synthase (HisFH) and the histidinol-phosphate phosphatase (HisN). The transcriptional organization of his genes in C. glutamicum is also reported, including the four histidine operons and their promoters. Knowledge of transcriptional regulation during stringent response and by histidine itself is summarized and a translational regulation mechanism is discussed, as well as clues about a histidine transport system. Finally, we discuss the potential of using this knowledge to create or improve C. glutamicum strains for the industrial l-histidine production.
登录
查看更多内容
影响因子：
8.4
作者：
Becker, Judith;Zelder, Oskar;Wittmann, Christoph
通讯作者：
Wittmann, Christoph
影响因子：
4.8
作者：
Cho, Y;Sharma, V;Sacchettini, JC
通讯作者：
Sacchettini, JC
影响因子：
4.1
作者：
Brinkrolf, Karina;Schroeder, Jasmin;Tauch, Andreas
通讯作者：
Tauch, Andreas
影响因子：
3.2
作者：
CHAPMAN, LF;NESTER, EW
通讯作者：
NESTER, EW
影响因子：
3.9
作者：
Brilli, M;Fani, R
通讯作者：
Fani, R