Behavioural sensitivity to binaural spatial cues in ferrets: evidence for plasticity in the duplex theory of sound localization.
Behavioural sensitivity to binaural spatial cues in ferrets: evidence for plasticity in the duplex theory of sound localization.
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DOI：
10.1111/ejn.12402
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
King AJ
中科院分区：
文献类型：
--
作者：
Keating P;Nodal FR;King AJ
一个多世纪以来，双工理论一直指导着我们对人类声音在水平面上定位的理解。根据这一理论，听觉系统分别利用耳间时间差（ITDs）和耳间电平差（ILDs）来定位低频和高频声音。虽然这一理论成功地解释了人类对音调的定位，但有些物种表现出非常不同的行为。雪貂被广泛用于研究空间听力的临床和基础方面，但目前尚不清楚双耳理论是否适用于雪貂，或者如果适用，每种双耳线索的频率范围在多大程度上取决于声学或神经生理因素。为了解决这些问题，我们对雪貂进行了训练，使其能够侧听耳机上呈现的音调，并发现在人类中观察到的ITD和ILD敏感性的频率依赖性大致相似。然而，与人类相比，ITD和ILD敏感性之间的转变向更高的频率转移。我们发现雪貂对ITD敏感性的频率依赖性可以部分地由声学因素来解释，尽管神经生理机制也可能参与其中。此外，我们表明双耳线索敏感性可以通过经验形成，因为训练雪貂在1 khz ILD任务上可以显著改善特定于训练线索和频率的阈值。我们的研究结果为限制不同声音定位线索使用的因素提供了新的见解，并强调了感官体验在塑造潜在神经机制中的重要性。
For over a century, the duplex theory has guided our understanding of human sound localization in the horizontal plane. According to this theory, the auditory system uses interaural time differences (ITDs) and interaural level differences (ILDs) to localize low-frequency and high-frequency sounds, respectively. Whilst this theory successfully accounts for the localization of tones by humans, some species show very different behaviour. Ferrets are widely used for studying both clinical and fundamental aspects of spatial hearing, but it is not known whether the duplex theory applies to this species or, if so, to what extent the frequency range over which each binaural cue is used depends on acoustical or neurophysiological factors. To address these issues, we trained ferrets to lateralize tones presented over earphones and found that the frequency dependence of ITD and ILD sensitivity broadly paralleled that observed in humans. Compared with humans, however, the transition between ITD and ILD sensitivity was shifted toward higher frequencies. We found that the frequency dependence of ITD sensitivity in ferrets can partially be accounted for by acoustical factors, although neurophysiological mechanisms are also likely to be involved. Moreover, we show that binaural cue sensitivity can be shaped by experience, as training ferrets on a 1-kHz ILD task resulted in significant improvements in thresholds that were specific to the trained cue and frequency. Our results provide new insights into the factors limiting the use of different sound localization cues and highlight the importance of sensory experience in shaping the underlying neural mechanisms.
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影响因子：
9.8
作者：
Kacelnik O;Nodal FR;Parsons CH;King AJ
通讯作者：
King AJ
影响因子：
3
作者：
Hartley, Douglas E. H.;Vongpaisal, Tara;Xu, Jin;Shepherd, Robert K.;King, Andrew J.;Isaiah, Amal
通讯作者：
Isaiah, Amal
DOI：
10.1007/978-1-4614-1590-9_31
发表时间：
2013-01-01
期刊：
BASIC ASPECTS OF HEARING: PHYSIOLOGY AND PERCEPTION
影响因子：
--
作者：
Jones, Heath G.;Koka, Kanthaiah;Tollin, Daniel J.
通讯作者：
Tollin, Daniel J.
DOI：
10.1007/s10162-013-0390-3
发表时间：
2013-08
影响因子：
2.4
作者：
Keating, Peter;Nodal, Fernando R.;Gananandan, Kohilan;Schulz, Andreas L.;King, Andrew J.
通讯作者：
King, Andrew J.
影响因子：
2.4
作者：
CARLILE, S
通讯作者：
CARLILE, S