Bilateral cochlear implantation in the ferret: a novel animal model for behavioral studies.
Bilateral cochlear implantation in the ferret: a novel animal model for behavioral studies.
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DOI：
10.1016/j.jneumeth.2010.05.014
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发表时间：
2010-07-15
影响因子：
3
通讯作者：
Isaiah, Amal
中科院分区：
文献类型：
--
作者：
Hartley, Douglas E. H.;Vongpaisal, Tara;Xu, Jin;Shepherd, Robert K.;King, Andrew J.;Isaiah, Amal
关键词：
双侧人工耳蜗植入术最近被引入，其目的是改善背景噪声中的言语感知和声音定位。虽然有证据表明，双耳感知是可能的两个人工耳蜗植入，结果在人类是可变的。为了探索这些变量结果的潜在影响因素，我们在一个新物种雪貂中建立了双侧人工耳蜗植入的行为动物模型。虽然雪貂非常适合双耳听力的心理物理和生理评估，但以前没有在这个物种中描述过人工耳蜗植入术。本文介绍了氨基糖苷类药物致聋技术、颅内阵列植入术和慢性颅内电刺激术，并监测电极完整性和刺激效果。其他地方的实验表明，该模型可用于研究长期植入动物双耳听力的行为和电生理测量。本文表明，人工耳蜗植入和慢性耳蜗内电刺激都是安全和有效的雪貂，开辟了可能性，使用该模型来研究潜在的保护作用，双侧人工耳蜗植入对发展中的中枢听觉通路。由于雪貂可用于评估听觉的心理物理和生理方面，沿着相同动物的听觉通路结构，我们预计该模型将有助于开发用于人类的新型神经假体疗法。
Bilateral cochlear implantation has recently been introduced with the aim of improving both speech perception in background noise and sound localization. Although evidence suggests that binaural perception is possible with two cochlear implants, results in humans are variable. To explore potential contributing factors to these variable outcomes, we have developed a behavioral animal model of bilateral cochlear implantation in a novel species, the ferret. Although ferrets are ideally suited to psychophysical and physiological assessments of binaural hearing, cochlear implantation has not been previously described in this species. This paper describes the techniques of deafening with aminoglycoside administration, surgical implantation of an intracochlear array and chronic intracochlear electrical stimulation with monitoring for electrode integrity and efficacy of stimulation. Experiments have been presented elsewhere to show that the model can be used to study behavioral and electrophysiological measures of binaural hearing in chronically implanted animals. This paper demonstrates that cochlear implantation and chronic intracochlear electrical stimulation are both safe and effective in ferrets, opening up the possibility of using this model to study potential protective effects of bilateral cochlear implantation on the developing central auditory pathway. Since ferrets can be used to assess psychophysical and physiological aspects of hearing along with the structure of the auditory pathway in the same animals, we anticipate that this model will help develop novel neuroprosthetic therapies for use in humans.
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