Molecular imaging in gastrointestinal endoscopy.

Molecular imaging in gastrointestinal endoscopy.
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DOI:
10.1053/j.gastro.2010.01.009
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发表时间:
2010-03
期刊:
影响因子:
29.4
通讯作者:
Wang TD
Wang TD
中科院分区:
医学1区
文献类型:
--
作者:
Goetz M;Wang TD

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分子成像是胃肠内窥镜中一门快速发展的新兴学科。它利用细胞的分子特征对胃肠道疾病进行微创、靶向成像。分子成像包括用于检测病变的广泛领域技术和用于体内表征的显微技术。外源性荧光剂作为分子信标,包括标记肽和抗体,以及具有肿瘤特异性激活的探针。大多数应用旨在通过原型荧光内窥镜或共聚焦内窥镜改善胃肠道肿瘤的检测,并且最初的研究已经将啮齿动物和组织模型的令人鼓舞的结果转化为人类内窥镜。即使目前使用的方法有局限性,分子成像也有可能对胃肠病学的内窥镜检查产生重大影响。
Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy. It uses the molecular signature of cells for minimally-invasive, targeted imaging of gastrointestinal pathologies. Molecular imaging comprises wide field techniques for the detection of lesions and microscopic techniques for in vivo characterization. Exogenous fluorescent agents serve as molecular beacons and include labeled peptides and antibodies, and probes with tumor-specific activation. Most applications have aimed at improving the detection of gastrointestinal neoplasia with either prototype fluorescence endoscopy or confocal endomicroscopy, and first studies have translated encouraging results from rodent and tissue models to endoscopy in humans. Even with the limitations of the currently used approaches, molecular imaging has the potential to greatly impact on future endoscopy in gastroenterology.
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