Plants as vectors for environmental prion transmission.
Plants as vectors for environmental prion transmission.
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DOI：
10.1016/j.isci.2023.108428
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发表时间：
2023-12-15
期刊：
影响因子：
5.8
通讯作者：
Pedersen, Joel A.
中科院分区：
文献类型：
--
作者：
Carlson, Christina M.;Thomas, Samuel;Keating, Matthew W.;Soto, Paulina;Gibbs, Nicole M.;Chang, Haeyoon;Wiepz, Jamie K.;Austin, Annabel G.;Schneider, Jay R.;Morales, Rodrigo;Johnson, Christopher J.;Pedersen, Joel A.
朊病毒会导致致命的神经退行性疾病，并表现出非凡的持久性，这会产生广泛的潜在接触场景。在鹿、麋鹿、驼鹿和驯鹿的慢性消耗性疾病中，以及绵羊和山羊的瘙痒症中，朊病毒通过环境途径传播，并且植物积累并随后传播朊病毒的能力已经被假设，但以前没有证明。在这里，我们建立了几种作物和其他植物物种的能力，采取朊病毒通过其根，并将它们从各种生长介质，包括土壤转移到地上组织。我们证明，植物可以积累朊病毒在地上组织的水平足以传播疾病后，口服摄入小鼠。我们的研究结果表明，植物可能作为载体朊病毒在环境中的传播-一个发现与野生动物保护，农业和公共卫生的影响。异常朊病毒蛋白可以进入植物的根部植物可以将可检测水平的朊病毒转移到气生组织动物暴露于朊病毒污染的植物组织可以获得疾病污染的植物可能是朊病毒暴露的途径生态学;生物科学;微生物学;植物生物学;植物与生物体的相互作用
Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In chronic wasting disease of deer, elk, moose, and reindeer and in scrapie of sheep and goats, prions are transmitted via environmental routes and the ability of plants to accumulate and subsequently transmit prions has been hypothesized, but not previously demonstrated. Here, we establish the ability of several crop and other plant species to take up prions via their roots and translocate them to above-ground tissues from various growth media including soils. We demonstrate that plants can accumulate prions in above-ground tissues to levels sufficient to transmit disease after oral ingestion by mice. Our results suggest plants may serve as vectors for prion transmission in the environment—a finding with implications for wildlife conservation, agriculture, and public health. Abnormal prion protein can enter the roots of plants Plants can translocate detectable levels of prions to aerial tissues Animals exposed to prion-contaminated plant tissues can acquire disease Contaminated plants may represent a route of prion exposure Ecology; Biological sciences; Microbiology; Plant biology; Interaction of plants with organisms
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影响因子：
4.4
作者：
Benestad SL;Mitchell G;Simmons M;Ytrehus B;Vikøren T
通讯作者：
Vikøren T
方案：一种改进的高通量方法，用于以96孔格式生成植物基因分型的组织样品（ICE-CAP 2.0）。
影响因子：
5.1
作者：
Clark KA;Krysan PJ
通讯作者：
Krysan PJ
影响因子：
6.4
作者：
LINSMAIER, EM;SKOOG, F
通讯作者：
SKOOG, F
影响因子：
3.8
作者：
BOLTON, DC;RUDELLI, RD;BENDHEIM, PE
通讯作者：
BENDHEIM, PE
影响因子：
11.8
作者：
Miller MW;Williams ES;Hobbs NT;Wolfe LL
通讯作者：
Wolfe LL