Environmental sources of prion transmission in mule deer.

Environmental sources of prion transmission in mule deer.
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DOI:
10.3201/eid1006.040010
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发表时间:
2004-06
影响因子:
11.8
通讯作者:
Wolfe LL
Wolfe LL
中科院分区:
医学2区
文献类型:
--
作者:
Miller MW;Williams ES;Hobbs NT;Wolfe LL

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鹿科动物中慢性消耗性疾病(CWD)朊病毒的传播是否需要与受感染动物的直接相互作用尚不清楚。我们报告说,慢性消耗病可以间接传播给易感动物,从环境污染的排泄物或腐烂的尸体。在实验条件下,黑尾鹿(Odocoileus hemionus)成为感染的两个三个围场含有自然感染的鹿,在两个三个围场感染的鹿尸体在原地分解1.8年前,在三个围场感染的鹿最后居住2.2年前。传染性朊病毒的间接传播和环境持久性将使控制慢性消耗病和其他动物朊病毒疾病的努力复杂化。
Whether transmission of the chronic wasting disease (CWD) prion among cervids requires direct interaction with infected animals has been unclear. We report that CWD can be transmitted to susceptible animals indirectly, from environments contaminated by excreta or decomposed carcasses. Under experimental conditions, mule deer (Odocoileus hemionus) became infected in two of three paddocks containing naturally infected deer, in two of three paddocks where infected deer carcasses had decomposed in situ ≈1.8 years earlier, and in one of three paddocks where infected deer had last resided 2.2 years earlier. Indirect transmission and environmental persistence of infectious prions will complicate efforts to control CWD and perhaps other animal prion diseases.
DOI: 10.7589/0090-3558-16.1.89
发表时间: 1980-01-01
影响因子: 1.3
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