Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study.
Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study.
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DOI：
10.1186/s10194-021-01263-1
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发表时间：
2021-06-07
期刊：
影响因子：
--
通讯作者：
Hirata K
中科院分区：
文献类型：
--
作者：
Suzuki K;Takeshima T;Igarashi H;Imai N;Danno D;Yamamoto T;Nagata E;Haruyama Y;Mitsufuji T;Suzuki S;Ito Y;Shibata M;Kowa H;Kikui S;Shiina T;Okamura M;Tatsumoto M;Hirata K
评估冠状病毒病2019(新冠肺炎)大流行引起的社会形势变化对日本偏头痛患者头痛相关残疾和其他症状的影响。我们进行了一项多中心、横断面研究，研究对象包括659名头痛专家诊断为偏头痛的门诊患者。参与者被问及第一波新冠肺炎疫情对头痛相关残疾、头痛天数、头痛强度、压力、体力活动、医院通道以及他们的工作和家庭生活的影响。对于头痛相关的残疾，分析偏头痛残疾评估(MIDAS)总分以及A、B部分得分。采用多元逐步线性回归分析确定新冠肺炎大流行前和期间MIDAS总分变化的临床预测因素。对新冠肺炎大流行期间新发头痛的相关因素进行Logistic回归分析。最后，606例偏头痛患者(男性73例，女性533例；年龄45.2 ± 12.0岁)纳入研究，排除资料不完整者。56.8%的受访者表示压力增加，55.1%的受访者对新冠肺炎感到担忧，45.0%的受访者认为第一波新冠肺炎疫情对日常生活产生了负面影响。在第一波新冠肺炎大流行后，MIDAS总分和A、B分没有明显变化。在Logistic回归分析中，95名患者(15.7 %)观察到新发头痛与年龄较小以及情绪和睡眠状况恶化有关。对新冠肺炎大流行第一波之前和期间MIDAS总分变化进行的多元逐步线性回归分析发现，睡眠恶化、急性用药增加、压力增加、药物短缺、并发症、缺乏先兆和新发头痛是新冠肺炎第一波期间MIDAS总分增加的决定因素。在这项多中心研究中，确定了与头痛相关残疾相关的临床因素，如新发头痛、压力和睡眠障碍，突显了在第一波新冠肺炎疫情期间偏头痛患者症状管理的重要性。网上版载有补充材料，可在10.1186/s10194-021-01263-1查阅。
To assess the impacts of social situation changes due to the coronavirus disease 2019 (COVID-19) pandemic on headache-related disability and other symptoms in patients with migraine in Japan. We conducted a multicentre, cross-sectional study including 659 outpatients with migraine diagnosed by headache specialists. The participants were asked about the impacts of the first wave of the COVID-19 pandemic on headache-related disability, headache days, headache intensity, stress, physical activity, hospital access and their work and home lives. For headache-related disability, the total Migraine Disability Assessment (MIDAS) score and part A and B scores were analysed. Multivariate stepwise linear regression analysis was performed to identify the clinical predictors of changes in the total MIDAS score before and during the COVID-19 pandemic. Logistic regression analysis was performed to determine the factors related to new-onset headache during the COVID-19 pandemic. Finally, 606 migraine patients (73 M/533 F; age, 45.2 ± 12.0 years) were included in the study, excluding those with incomplete data. Increased stress, substantial concern about COVID-19 and negative impacts of the first wave of the COVID-19 pandemic on daily life were reported in 56.8 %, 55.1 and 45.0 % of the participants, respectively. The total MIDAS and A and B scores did not significantly change after the first wave of the COVID-19 pandemic. New-onset headache, which was observed in 95 patients (15.7 %), was associated with younger age and worsened mood and sleep in the logistic regression analysis. The multivariate stepwise linear regression analysis of changes in the total MIDAS score before and during the first wave of COVID-19 pandemic identified worsened sleep, increased acute medication use, increased stress, medication shortages, comorbidities, the absence of an aura and new-onset headache were determinants of an increased total MIDAS score during the first wave of the COVID-19 pandemic. In this multicentre study, clinical factors relevant to headache-related disability, such as new-onset headache, stress and sleep disturbances, were identified, highlighting the importance of symptom management in migraine patients during the first wave of the COVID-19 pandemic. The online version contains supplementary material available at 10.1186/s10194-021-01263-1.
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