Plasma N-glycans in colorectal cancer risk.
Plasma N-glycans in colorectal cancer risk.
复制标题
DOI：
10.1038/s41598-018-26805-7
复制
发表时间：
2018-06-05
影响因子：
4.6
通讯作者：
Rudd PM
中科院分区：
文献类型：
--
作者：
Doherty M;Theodoratou E;Walsh I;Adamczyk B;Stöckmann H;Agakov F;Timofeeva M;Trbojević-Akmačić I;Vučković F;Duffy F;McManus CA;Farrington SM;Dunlop MG;Perola M;Lauc G;Campbell H;Rudd PM
异常糖基化与包括癌症在内的许多疾病有关。我们的目的是阐明全血浆N-糖基化结直肠癌（CRC）的情况下，控制在其最大的队列之一。一组633例CRC患者和478例年龄和性别匹配的对照进行了分析。此外，患者被分为四个CRC阶段。此外，在最初诊断CRC之前收集的40名患者的血浆中进行N-聚糖分析。在CRC的所有阶段，在血浆N-糖组中观察到统计学显著差异，这包括与核心岩藻糖基化双触角聚糖F（6）A2 G2和F（6）A2 G2 S（6）1相关的高度显著降低（P < 0.0009）。与阶段2、3和4相比，阶段1显示出独特的生物标志物特征。有迹象表明，可以从糖组中识别出风险组（回顾性AUC = 0.77，前瞻性AUC = 0.65）。与疾病的致病性进展相关的N-糖组生物标志物在临床环境中将是相当大的资产，并且它可以使得能够开发新的治疗剂以靶向处于进展风险的患者中的疾病。
Aberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasma N-glycosylation between colorectal cancer (CRC) cases and controls in one of the largest cohorts of its kind. A set of 633 CRC patients and 478 age and gender matched controls was analysed. Additionally, patients were stratified into four CRC stages. Moreover, N-glycan analysis was carried out in plasma of 40 patients collected prior to the initial diagnosis of CRC. Statistically significant differences were observed in the plasma N-glycome at all stages of CRC, this included a highly significant decrease in relation to the core fucosylated bi-antennary glycans F(6)A2G2 and F(6)A2G2S(6)1 (P < 0.0009). Stage 1 showed a unique biomarker signature compared to stages 2, 3 and 4. There were indications that at risk groups could be identified from the glycome (retrospective AUC = 0.77 and prospective AUC = 0.65). N-glycome biomarkers related to the pathogenic progress of the disease would be a considerable asset in a clinical setting and it could enable novel therapeutics to be developed to target the disease in patients at risk of progression.
登录
查看更多内容
影响因子：
64.5
作者：
Dennis JW;Nabi IR;Demetriou M
通讯作者：
Demetriou M
影响因子：
--
作者：
Ercan, Altan;Barnes, Michael G.;Nigrovic, Peter A.
通讯作者：
Nigrovic, Peter A.
影响因子：
5.5
作者：
Collins, Emily S.;Galligan, Marie C.;FitzGerald, Oliver
通讯作者：
FitzGerald, Oliver
影响因子：
4.4
作者：
Hamfjord, Julian;Saldova, Radka;Kure, Elin H.
通讯作者：
Kure, Elin H.
影响因子：
2
作者：
Croce, MV;Sálice, VC;Segal-Eiras, A
通讯作者：
Segal-Eiras, A