Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall.
Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall.
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DOI：
10.1002/hbm.22403
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发表时间：
2014-07
影响因子：
4.8
通讯作者：
Moll, Jorge
中科院分区：
文献类型：
--
作者：
Bado, Patricia;Engel, Annerose;de Oliveira-Souza, Ricardo;Bramati, Ivanei E.;Paiva, Fernando F.;Basilio, Rodrigo;Sato, Joao R.;Tovar-Moll, Fernanda;Moll, Jorge
人类一生中有相当一部分时间是在走神。这种自发的思维活动通常包括自传式回忆、情感和自我参照成分。虽然神经影像学研究已经证明，特定的大脑“默认模式网络”（DMN）一直被大脑的“静息状态”所参与，但关键认知成分对DMN活动的相对贡献仍然知之甚少。在这里，我们使用功能磁共振成像来研究DMN神经成分的活动是否可以通过积极回忆相关的情绪自传体记忆来解释，而不是静息状态。我们的研究设计结合了情绪自传体记忆、中性记忆和静息状态条件，并通过一系列减法控制任务进行分离。与连续减法相比，在情绪自传体和静息条件下，DMN的激活模式都是相同的。自传体和静息状态的直接对比表明，DMN内部存在显著的分离，情绪性自传体检索导致背内侧核心区域（内侧前额叶皮层、后扣带皮层）的更强激活，而静息状态除了IPL外，还涉及额叶腹侧网络（腹侧纹状体、亚属和腹侧前扣带皮层）。我们的结果揭示了DMN内尚未报道的解离。背内侧部分可以用情绪自传式记忆来解释，而腹额侧部分则主要与静息状态有关，可能是自发无约束思维过程中参与的基本动机机制。中国生物医学工程学报（英文版），2014。©2013作者人脑图谱由Wiley期刊公司出版。
Humans spend a substantial share of their lives mind‐wandering. This spontaneous thinking activity usually comprises autobiographical recall, emotional, and self‐referential components. While neuroimaging studies have demonstrated that a specific brain “default mode network” (DMN) is consistently engaged by the “resting state” of the mind, the relative contribution of key cognitive components to DMN activity is still poorly understood. Here we used fMRI to investigate whether activity in neural components of the DMN can be differentially explained by active recall of relevant emotional autobiographical memories as compared with the resting state. Our study design combined emotional autobiographical memory, neutral memory and resting state conditions, separated by a serial subtraction control task. Shared patterns of activation in the DMN were observed in both emotional autobiographical and resting conditions, when compared with serial subtraction. Directly contrasting autobiographical and resting conditions demonstrated a striking dissociation within the DMN in that emotional autobiographical retrieval led to stronger activation of the dorsomedial core regions (medial prefrontal cortex, posterior cingulate cortex), whereas the resting state condition engaged a ventral frontal network (ventral striatum, subgenual and ventral anterior cingulate cortices) in addition to the IPL. Our results reveal an as yet unreported dissociation within the DMN. Whereas the dorsomedial component can be explained by emotional autobiographical memory, the ventral frontal one is predominantly associated with the resting state proper, possibly underlying fundamental motivational mechanisms engaged during spontaneous unconstrained ideation. Hum Brain Mapp 35:3302–3313, 2014. © 2013 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc..
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Bellgowan, PSF;Bandettini, PA;Bodurka, J
通讯作者：
Bodurka, J
影响因子：
5.7
作者：
FRISTON, KJ;FRITH, CD;FRACKOWIAK, RSJ
通讯作者：
FRACKOWIAK, RSJ
影响因子：
2.5
作者：
Fukunaga, Masaki;Horovitz, Silvina G.;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
16.2
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Sepulcre, Jorge;Poulin, Renee;Buckner, Randy L.
通讯作者：
Buckner, Randy L.