Functional-anatomic fractionation of the brain's default network.

Functional-anatomic fractionation of the brain's default network.
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DOI:
10.1016/j.neuron.2010.02.005
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发表时间:
2010-02-25
期刊:
影响因子:
16.2
通讯作者:
Buckner, Randy L.
Buckner, Randy L.
中科院分区:
医学1区
文献类型:
--
作者:
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Sepulcre, Jorge;Poulin, Renee;Buckner, Randy L.

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人类功能成像中最一致的观察结果之一是,被称为“默认网络”的大脑区域网络在被动状态下增加了其活动。在这里,我们探讨了三项研究中默认网络的解剖和功能,以解决关于其对自发思维和主动决策形式的贡献的不同假设。对内在活动的分析表明,该网络包括多个分离的组件。当人们做出与自我相关的情感决定时,中线核心(后扣带回和前内侧前额叶皮层)是活跃的。与此相反,当决策涉及构建基于记忆的心理场景时,内侧颞叶子系统就会参与其中。在未来导向思维的某些实验导向和自发行为中,这些分离的成分同时参与,可能是为了促进对个人重要事件的心理模型的构建。
One of the most consistent observations in human functional imaging is that a network of brain regions referred to as the “default network” increases its activity during passive states. Here we explored the anatomy and function of the default network across three studies to resolve divergent hypotheses about its contributions to spontaneous thought and active forms of decision-making. Analysis of intrinsic activity revealed the network comprises multiple, dissociated components. A midline core (posterior cingulate and anterior medial prefrontal cortex) is active when people make self-relevant, affective decisions. In contrast, a medial temporal lobe subsystem becomes engaged when decisions involve constructing a mental scene based on memory. During certain experimentally-directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged presumably to facilitate construction of mental models of personally-significant events.
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发表时间: 2007-12-26
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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