Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson's Disease.
Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson's Disease.
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α-突触核蛋白诱导免疫细胞激活及帕金森病的相关治疗。
DOI：
10.3389/fnagi.2021.769506
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhou T
中科院分区：
文献类型：
--
作者：
Su R;Zhou T
帕金森病是一种与免疫密切相关的神经退行性疾病。PD发病机制的一个重要方面是α-突触核蛋白与一系列免疫细胞之间的相互作用。研究表明，α-突触核蛋白的积累可诱导加速PD进展的自身免疫反应。本研究探讨了α-突触核蛋白与免疫系统相互作用的机制。在PD的发展过程中，异常积累的α-突触核蛋白成为一种自身免疫抗原，与Toll样受体（TLR）结合，激活小胶质细胞，从而分化为小胶质细胞1型（M1）亚型。小胶质细胞激活细胞内炎症通路，诱导促炎细胞因子的释放，并促进分化簇4 +（CD 4+）T细胞分化为促炎性辅助性T细胞1型（Th 1）和辅助性T细胞17型（Th 17）亚型。鉴于α-突触核蛋白在PD患者免疫系统中的重要作用，确定与α-突触核蛋白相关的免疫治疗的潜在靶点对于减缓疾病进展至关重要。对PD免疫相关机制的深入了解可以指导未来相关治疗策略的发展。
Parkinson’s disease (PD) is a neurodegenerative disorder closely related to immunity. An important aspect of the pathogenesis of PD is the interaction between α-synuclein and a series of immune cells. Studies have shown that accumulation of α-synuclein can induce an autoimmune response that accelerates the progression of PD. This study discusses the mechanisms underlying the interaction between α-synuclein and the immune system. During the development of PD, abnormally accumulated α-synuclein becomes an autoimmune antigen that binds to Toll-like receptors (TLRs) that activate microglia, which differentiate into the microglia type 1 (M1) subtype. The microglia activate intracellular inflammatory pathways, induce the release of proinflammatory cytokines, and promote the differentiation of cluster of differentiation 4 + (CD4 +) T cells into proinflammatory T helper type 1 (Th1) and T helper type 17 (Th17) subtypes. Given the important role of α-synuclein in the immune system of the patients with PD, identifying potential targets of immunotherapy related to α-synuclein is critical for slowing disease progression. An enhanced understanding of immune-associated mechanisms in PD can guide the development of associated therapeutic strategies in the future.
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影响因子：
6.1
作者：
Thomas Broome S;Louangaphay K;Keay KA;Leggio GM;Musumeci G;Castorina A
通讯作者：
Castorina A
影响因子：
5.5
作者：
Angelova DM;Brown DR
通讯作者：
Brown DR
影响因子：
16.6
作者：
Choi, Insup;Zhang, Yuanxi;Yue, Zhenyu
通讯作者：
Yue, Zhenyu
影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane
影响因子：
3.3
作者：
Caggiu, E.;Paulus, K.;Sechi, L. A.
通讯作者：
Sechi, L. A.