Prevalence of low bone mineral density in a low-income inner-city population.
Prevalence of low bone mineral density in a low-income inner-city population.
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DOI：
10.1002/jbmr.221
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发表时间：
2011-02
影响因子：
6.2
通讯作者：
Brown, Todd T.
中科院分区：
文献类型：
--
作者：
El-Maouche, Diala;Xu, Xiaoqiang;Cofrancesco, Joseph, Jr.;Dobs, Adrian S.;Brown, Todd T.
骨矿物质密度（BMD）是与骨骼健康相关的重要因素。在城市服务不足的人群中，低BMD的患病率及其相关的危险因素知之甚少。在2001年至2004年期间，我们招募了338名受试者，他们完成了药物使用和病史问卷，进行了激素测量，并进行了全身双能X线吸收测定法（DXA），以评估BMD和身体成分。其中，132例受试者进行了部位特异性DXA（腰椎和髋关节）。根据国家骨质疏松基金会（NOF）指南，骨质疏松症定义为50岁及以上男性和绝经后女性的腰椎、全髋关节或股骨颈T评分为-2.5或更低，50岁以下男性和绝经前女性的Z评分为-2.0或更低。该队列主要由非裔美国人组成，中年人非法药物使用率高，50%的HIV+和39%的丙型肝炎+。在22%的受试者（24名男性，5名女性）中发现骨质疏松症，大多数病例（90%）可归因于腰椎骨质疏松症。骨质疏松症在男性中比在女性中更常见。女性较低的全身BMD与多种危险因素相关，但仅与男性较低的瘦体重相关。骨质疏松症在男性中非常普遍，主要发生在脊柱。该人群中骨丢失的危险因素需要进一步阐明。考虑到多种危险因素和低BMD的意外高患病率，在50岁开始筛查男性骨质疏松症可能是必要的。© 2011美国骨与矿物质研究学会。
Bone mineral density (BMD) is an important factor linked to bone health. Little is known of the prevalence of low BMD and its associated risk factors in an urban underserved population. Between 2001 and 2004, we recruited 338 subjects who completed drug use and medical history questionnaires, underwent hormonal measurements, and underwent whole-body dual-energy X-ray absorptiometry (DXA) for evaluation of BMD and body composition. Of these, 132 subjects had site-specific DXA (lumbar spine and hip) performed. Osteoporosis was defined as a T-score of –2.5 or less for men 50 years of age and older and postmenopausal women and a Z-score of –2.0 or less in men younger than 50 years of age and premenopausal women at either the lumbar spine, total hip, or femoral neck, according to National Osteoporosis Foundation (NOF) guidelines. The cohort consisted of mostly African-American, middle-aged people with a high prevalence of illicit drug use, 50% HIV+, and 39% hepatitis C+. Osteoporosis was identified in 22% of subjects (24 men, 5 women), with the majority of cases (90%) attributable to osteoporosis at the lumbar spine. Osteoporosis was more common in men than in women. Lower whole-body BMD among women was associated with multiple risk factors, but only with lower lean mass among men. Osteoporosis was highly prevalent in men, mainly at the spine. The risk factors for bone loss in this population need to be further clarified. Screening men for osteoporosis starting at age 50 might be warranted in this population given the multiple risk factors and the unexpectedly high prevalence of low BMD. © 2011 American Society for Bone and Mineral Research.
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